Distortion of Mendelian segregation across the Angus cattle genome uncovering regions affecting reproduction
Id-Lahoucine, Samir (University of Guelph. Department of Animal Biosciences)
Casellas Vidal, Joaquim (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Lu, Duc (Angus Genetics Inc)
Sargolzaei, Mehdi (Select Sires, Inc)
Miller, Stephen (University of New England. Department of Primary Industries)
Cánovas, Angela (University of Guelph. Department of Animal Biosciences)

Date:	2023
Abstract:	Nowadays, the availability of genotyped trios (sire-dam-offspring) in the livestock industry enables the implementation of the transmission ratio distortion (TRD) approach to discover deleterious alleles in the genome. Various biological mechanisms at different stages of the reproductive cycle such as gametogenesis, embryo development and postnatal viability can induce signals of TRD (i. e. , deviation from Mendelian inheritance expectations). In this study, TRD was evaluated using both SNP-by-SNP and sliding windows of 2-, 4-, 7-, 10- and 20-SNP across 92,942 autosomal SNPs for 258,140 genotyped Angus cattle including 7,486 sires, 72,688 dams and 205,966 offspring. Transmission ratio distortion was characterized using allelic (specific- and unspecific-parent TRD) and genotypic parameterizations (additive- and dominance-TRD). Across the Angus autosomal chromosomes, 851 regions were clearly found with decisive evidence for TRD. Among these findings, 19 haplotypes with recessive patterns (potential lethality for homozygote individuals) and 52 regions with allelic patterns exhibiting complete or quasi-complete absence for homozygous individuals in addition to under-representation (potentially reduced viability) of the carrier (heterozygous) offspring were found. In addition, 64 (12) and 20 (4) regions showed significant influence on the trait heifer pregnancy at p-value < 0. 05 (after chromosome-wise false discovery rate) and 0. 01, respectively, reducing the pregnancy rate up to 15%, thus, supporting the biological importance of TRD phenomenon in reproduction.
Note:	Altres ajuts: Agriculture and Agri-Food Canada's Canadian Agricultural Partnership FDE.13.17
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Animal breeding ; Genomics
Published in:	Scientific reports, Vol. 13 (august 2023) , ISSN 2045-2322

DOI: 10.1038/s41598-023-37710-z
PMID: 37591956

10 p, 1004.8 KB

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