Granuloprival cerebellar cortical degeneration in a and dog
Mignan, Thomas (Dovecote Veterinary Hospital)
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Platt, Simon (CVS Teleneurology)
James, Matthew (Dovecote Veterinary Hospital)
Pereira, Marta (University of Nottingham. School of Veterinary Medicine and Science)
Morey-Matamalas, Antonia (University of Nottingham. School of Veterinary Medicine and Science)
Recio, Alfredo (Clínica Veterinaria Levante)

Date:	2024
Abstract:	Granuloprival degeneration is an uncommon form of cerebellar cortical degeneration (CCD). A 3-month-old Yorkshire Terrier and a 7-month-old Lagotto Romagnolo dog were presented with a history of progressive cerebellar dysfunction including wide-based stance, cerebellar ataxia, intention tremors, and loss of menace response despite normal vision. Magnetic resonance imaging of the brain identified marked diffuse decrease of the cerebellum size. Euthanasia was performed in both cases because of progression of clinical signs. Histopathological examination identified marked diffuse thinning of the granular cell layer with almost complete loss of the granular cell neurons, providing a definitive diagnosis of granuloprival CCD. Granuloprival CCD should be considered as a differential diagnosis in Yorkshire Terrier and Lagotto Romagnolo dogs with post-natal progressive clinical signs of cerebellar dysfunction.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Abiotrophy ; Canine ; Cerebellum ; Degenerative ; Granular cell
Published in:	Journal of Veterinary Internal Medicine, Vol. 38 (april 2024) , p. 2368-2372, ISSN 1939-1676

DOI: 10.1111/jvim.17091
PMID: 38662636

5 p, 1.1 MB

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