Dual responsive polymersomes as versatile, intelligent labeling system in biosensing
Quinchia, Jennifer (University of Antioquia)
Cruz-Pacheco, Andrés F. (University of Antioquia)
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)
Orozco, Jahir (University of Antioquia)

Fecha:	2024
Resumen:	The ability to manipulate artificial nanosystems is still one of the current challenges in devel-oping multifunctional nanomaterials. Those based on the photochromic effect are particularly interesting because of structural and functional control by the transient activation/inactivation with high spatiotemporal resolution. To mimic the photocontrol of natural nanosystems, we developed the first photochromic polymersomes from the novel poly(ethylene-alt-maleic an-hydride)-random-aminoazobenzene copolymer (PEMA-r-AAB) and its derivatives. Ultraviolet (UV)-triggered azobenzene (AZO) moieties' medium-dependent isomerization from non-polar trans- to polar cis-AZO controls polymersome's bilayer selective permeability. As a result, small hydrophilic molecules loaded inside polymersomes can be released according to the release profiles, while those outside the polymersome bilayer can eventually penetrate it. Remarkably, as a new look, cargo photorelease from the nanopolymersomes was studied in real-time by cyclic voltammetry (CV). Finally, as a proof-of-concept, horseradish peroxidase (HRP)-loaded polymersomes were assembled as an intelligent labeling system of an optical biosensor of interleukin-6 (IL-6). This synthesis route can be exploited with other photo-switching AZO derivatives, paving the way toward new AZO compound-based nanocarrier systems.
Ayudas:	Agencia Estatal de Investigación PID2021-127983OB-C21
Derechos:	Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió sotmesa a revisió
Materia:	AZO compounds ; Photochromism ; Real-time cyclic voltammetry studies ; Smart labeling system ; Smart polymersome ; UV-induced medium-dependent cargo release
Publicado en:	Chemical engineering journal (1996), Vol. 500 (November 2024) , art. 157165, ISSN 1873-3212

DOI: 10.1016/j.cej.2024.157165

Preprint 38 p, 1.5 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias > Institut Català de Nanociència i Nanotecnologia (ICN2)
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