The nanoparticle-Protein Corona untold history (1907-2007)
Casals, Eudald (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Vitali, Michele (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)

Date:	2024
Abstract:	The adsorption of biomolecules, primarily proteins, on the surfaces of nanoparticles plays a crucial role in elucidating the safe application of nanotechnology, especially in medicine. Termed the "Protein Corona" since 2007, this phenomenon remains of general interest and continues to be subject to intensive research today. Notably, dating back to the XIX century, a large body of early work has addressed the adsorption of proteins onto different surfaces, from colloids to implants. Standing on the shoulders of this historical knowledge could deepen our understanding of the Protein Corona and its biological implications. Herein, we aim to trace the historical trajectory before 2007, combining earlier scientific evidence and findings with contemporary research on the topic. Such insights will contribute to helping and guiding further research into the Protein Corona, thereby accelerating the clinical and societal translation of nanobiotechnology and nanomedicine.
Grants:	Agencia Estatal de Investigación RTI2018-099965-B-I00 Agencia Estatal de Investigación PCI2019-103436 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00878 Agencia Estatal de Investigación SEV-2017-0706
Note:	Altres ajuts: CERCA Programme/Generalitat de Catalunya
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió acceptada per publicar
Subject:	Protein Corona ; Protein Adsorption ; Proteins at Interfaces ; Colloids
Published in:	Nano Today, Vol. 58 (October 2024) , art. 102435, ISSN 1878-044X

DOI: 10.1016/j.nantod.2024.102435

Available from: 2026-10-31 Postprint

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles