Assessing the effect of β-glucan diets on innate immune response of tilapia macrophages against trichlorfon exposure : an in vitro study
Fierro-Castro, Camino (Universidad de León. Departamento de Biología Molecular)
Tort Bardolet, Lluís (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Mingatto, Fábio Erminio (São Paulo State University. Department of Animal Science)
Biller, Jaqueline Dalbello (São Paulo State University. Department of Animal Science)

Fecha:	2023
Resumen:	The widespread use of pesticides in some areas where fish species such as tilapia are farmed may cause damage to the environment and affect commercial fish and therefore, human health. Water leaching with the pesticide trichlorfon, during the fumigation season in the field, can affect water quality in fish farms and consequently affect fish health. At the same time, the use of immunomodulatory compounds such as β-glucan supplied in the diet has become widespread in fish farms as it has been shown that improves the overall immune response. The present research examines the immunomodulatory impacts observed in macrophages of Nile tilapia (Oreochromis niloticus) after being fed a diet supplemented with β-glucan for 15 days, followed by their in vitro exposure to trichlorfon, an organophosphate pesticide, at concentrations of 100 and 500 µg mL-1 for 24 h. The results showed that β-glucan diet improved the viability of cells exposed to trichlorfon and their antioxidant capacity. However, β-glucan did not counteract the effects of the pesticide as for the ability to protect against bacterial infection. From the present results, it can be concluded that β-glucan feeding exerted a protective role against oxidative damage in cells, but it was not enough to reduce the deleterious effects of trichlorfon on the microbicidal capacity of macrophages exposed to this pesticide.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Aquatic contaminants ; Trichlorfon ; Organophosphates ; Innate immunity ; Immunomodulation ; Macrophages ; Oreochromis niloticus
Publicado en:	Fish Physiology and Biochemistry, Vol. 50 (December 2023) , p. 527-541, ISSN 1573-5168

DOI: 10.1007/s10695-023-01283-5
PMID: 38099984

15 p, 1.3 MB

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