Metabolic insights and background from naturally affected pigs during Streptococcus suis outbreaks
Fabà, Lluís (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Aragón, Virginia (Universitat Autònoma de Barcelona. Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal)
Litjens, Ralph (Trouw Nutrition R&D)
Galofré Milà, Núria (Universitat Autònoma de Barcelona. Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal)
Segura, Mariela (University of Montreal)
Gottschalk, Marcelo (University of Montreal)
Doelman, John (Trouw Nutrition R&D)

Fecha:	2023
Resumen:	Streptococcus suis ( S. suis ) is an endemic zoonotic pathogen still lacking adequate prevention in pigs. The present case study looked back to the occurrence and consequences of S. suis outbreaks in our swine research facilities in search of new metabolic and physiological insight. From a series of outbreaks, a dataset was created including 56 pigs sampled during disease detection based on clinical signs. Pigs suspected with S. suis infection were defined as diseased (n = 28) and included pigs defined as neurologically diseased (n = 20) when severe neurological signs (central nervous system dysfunctions, i. e. , opisthotonos, ataxia, and generalized tremor) were observed. Another set of 28 pigs included respective pen mates from each case and were defined as control. Representative deaths were confirmed to be caused by S. suis. Tonsillar swabs were collected and analyzed by quantitative polymerase chain reaction (qPCR) for total bacteria, total S. suis, and S. suis serotypes (SS) 2 (and/or 1/2) and 9. Blood and sera were analyzed to quantify blood gases, minerals, and S. suis reactive immunoglobulins against current isolates. Data collected included litter sibling associations, birth and weaning body weight (BW), and average daily gain (ADG) 7 d after the disease detection. In general, the disease increased pH, sO and the incidence of alkalosis, but reduced pCO, glucose, Ca, P, Mg, K, and Na in blood/serum compared to control. The SS2 (and/or SS1/2) prevalence was significantly (P < 0. 05) increased in neurologically diseased pigs and its relative abundance tended (P < 0. 10) to increase in tonsils. In contrast, the relative abundance of total S. suis was lower (P.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Immunoglobulins ; Meningitis ; Minerals ; Nursery pig ; Streptococcus suis
Publicado en:	Translational Animal Science, Vol. 7 (november 2023) , ISSN 2573-2102

DOI: 10.1093/tas/txad126
PMID: 38023423

12 p, 613.0 KB

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