Recent developments in alkene oxo-functionalization reactions governed by photoredox methods
Sarró, Pau (Universitat Autònoma de Barcelona. Departament de Química)
Ji, Yingmin (Universitat Autònoma de Barcelona. Departament de Química)
Gallego-Gamo, Albert (Universitat Autònoma de Barcelona. Departament de Química)
Gimbert Suriñach, Carolina (Universitat Autònoma de Barcelona. Departament de Química)
Vallribera Massó, Adelina (Universitat Autònoma de Barcelona. Departament de Química)
Granados Toda, Albert (Universitat Autònoma de Barcelona. Departament de Química)

Imprint:	Royal society of chemistry, 2025
Abstract:	Alkene oxo-functionalization reactions have emerged as a powerful tool in modern synthetic organic chemistry, enabling the sequential formation of carbonyl (C[double bond, length as m-dash]O) and various C-R bonds (R = alkyl, aryl, oxygen-, sulfur-, nitrogen- or phosphorus-compounds). Recent advances in photoredox catalysis have propelled the development of these transformations by enabling the use of mild, selective, and sustainable reaction conditions. This review provides an analysis of recent methods for alkene oxo-functionalization under photoredox conditions, with a focus on the synthesis of multifunctionalized products through single and tandem processes. Mechanistic insights into radical generation, photoexcitation pathways and oxygen sources are discussed to highlight the unique role of photoredox catalysis in these transformations. Additionally, we examine the substrate scope, functional group tolerance, and potential applications of these reactions in complex molecule synthesis and drug development. Finally, current challenges and future perspectives in the field are discussed, emphasizing how innovative photoredox approaches continue to expand new opportunities for the selective construction of C[double bond, length as m-dash]O and C-R bonds in organic synthesis.
Grants:	Agencia Estatal de Investigación RED2022-134287-T Agencia Estatal de Investigación PID2021-124916NB-I00 Agencia Estatal de Investigación PID2021-128496OB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00064
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Alkene
Published in:	Organic chemistry frontiers, Vol. 12, issue 11 (June 2025) , p. 3475-3492, ISSN 2052-4129

DOI: 10.1039/D5QO00236B

18 p, 5.2 MB

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Articles > Research articles
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