Advancing yeast metabolism for a sustainable single carbon bioeconomy
Kuzman, Miriamb (BOKU University)
Ata, Özge (Austrian Centre of Industrial Biotechnology (ACIB))
Mattanovich, Diethard (BOKU University)

Fecha:	2025
Resumen:	Single carbon (C1) molecules are considered as valuable substrates for biotechnology, as they serve as intermediates of carbon dioxide recycling, and enable bio-based production of a plethora of substances of our daily use without relying on agricultural plant production. Yeasts are valuable chassis organisms for biotech production, and they are able to use C1 substrates either natively or as synthetic engineered strains. This minireview highlights native yeast pathways for methanol and formate assimilation, their engineering, and the realization of heterologous C1 pathways including CO2, in different yeast species. Key features determining the choice among C1 substrates are discussed, including their chemical nature and specifics of their assimilation, their availability, purity, and concentration as raw materials, as well as features of the products to be made from them.
Ayudas:	European Commission 101000441
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Methanol ; Formate ; Carbon dioxide ; Bioeconomy ; Sustainability
Publicado en:	FEMS yeast research, Vol. 25 (April 2025) , art. foaf020, ISSN 1567-1364

DOI: 10.1093/femsyr/foaf020
PMID: 40246696

11 p, 1.1 MB

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