Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
Bastard, Paul (Paris Cité University. Imagine Institute)
Gervais, A. (University Paris Citè. Imagine Institute)
Taniguchi, M. (Dept. of Pediatrics. Graduate School of Biomedical and Health Sciences. Hiroshima University)
Saare, L. (Dept. of Pediatrics. Institute of Clinical Medicine. University of Tartu)
Särekannu, K. (Molecular Pathology. Institute of Biomedicine and Translational Medicine. University of Tartu)
Voyer, T.L. (University Paris Citè. Imagine Institute)
Philippot, Q. (University Paris Citè. Imagine Institute)
Rosain, J. (University Paris Citè. Imagine Institute)
Bizien, L. (University Paris Citè. Imagine Institute)
Asano, T. (Dept. of Pediatrics. Graduate School of Biomedical and Health Sciences. Hiroshima University)
Garcia-Prat, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Parra-Martínez, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Migaud, M. (University Paris Citè. Imagine Institute)
Tsumura, M. (Dept. of Pediatrics. Graduate School of Biomedical and Health Sciences. Hiroshima University)
Conti, F. (Dept. of Medical and Surgical Sciences. Alma Mater Studiorum. University of Bologna)
Belot, Alexandre (Pediatric Nephrology. Rheumatology. Dermatology. HFME. Hospices Civils de Lyon. National Referee Centre RAISE. INSERM U1111. Université de Lyon)
Rivière, Jacques G. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Morio, T. (Tokyo Medical & Dental University Hospital)
Tanaka, J. (Dept. of Epidemiology. Infectious Disease Control and Prevention. Graduate School of Biomedical and Health Sciences. Hiroshima University)
Javouhey, E. (Pediatric Intensive Care Unit. Hospices Civils de Lyon. Hopital Femme Mère Enfant)
Haerynck, F. (Department of Paediatric Immunology and Pulmonology. Centre for Primary Immunodeficiency Ghent (CPIG). PID Research Laboratory. Jeffrey Modell Diagnosis and Research Centre. Ghent University Hospital)
Duvlis, S. (Institute of Public Health of the Republic of North Macedonia)
Ozcelik, Tayfun (Bilkent University)
Keles, S. (Meram Medical Faculty. Necmettin Erbakan University)
Tandjaoui-Lambiotte, Y. (INSERM UMR 1272 Hypoxia and Lung)
Escoda, S. (Pediatric Dept.. Saint-Denis Hospital)
Husain, M. (Pediatric Dept.. Saint-Denis Hospital)
Pan-Hammarström, Q. (Karolinska Institutet (Estocolm, Suècia). Department of Biosciences and Nutrition)
Hammarström, L. (Karolinska Institutet (Estocolm, Suècia). Department of Biosciences and Nutrition)
Ahlijah, G. (Laboratory of Human Genetics of Infectious Diseases. Necker Branch. INSERM U1163. Necker Hospital for Sick Children)
Haidar, A.A. (Laboratory of Human Genetics of Infectious Diseases. Necker Branch. INSERM U1163. Necker Hospital for Sick Children)
Soudee, C. (Laboratory of Human Genetics of Infectious Diseases. Necker Branch. INSERM U1163. Necker Hospital for Sick Children)
Arseguel, V. (Laboratory of Human Genetics of Infectious Diseases. Necker Branch. INSERM U1163. Necker Hospital for Sick Children)
Abolhassani, Hassan (Research Center for Immunodeficiencies. Pediatrics Center of Excellence. Children's Medical Center. Pediatrics Center of Excellence. Tehran University of Medical Sciences)
Sahanic, S. (Dept. of Internal Medicine II. Medical University of Innsbruck)
Tancevski, I. (Department of Internal Medicine II. Medical University of Innsbruck)
Nukui, Y. (Dept. of Infection Control and Prevention. Medical Hospital. TMDU)
Hayakawa, S. (Dept. of Pediatrics. Graduate School of Biomedical and Health Sciences. Hiroshima University)
Chrousos, G.P. (University Research Institute of Maternal and Child Health and Precision Medicine. National and Kapodistrian University of Athens)
Michos, A. (First Dept. of Pediatics. National and Kapodistrian University of Athens)
Tatsi, E.B. (First Dept. of Pediatics. National and Kapodistrian University of Athens)
Filippatos, F. (First Dept. of Pediatics. National and Kapodistrian University of Athens)
Rodriguez-Palmero, A. (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Troya, Jesús (Dept. of Internal Medicine. Infanta Leonor University Hospital)
Tipu, I. (University of Management and Technology)
Meyts, I. (Laboratory for Inborn Errors of Immunity. KU Leuven)
Roussel, L. (Infectious Disease Susceptibility Program. Research Institute-McGill University Health Centre)
Ostrowski, S.R. (Dept. of Clinical Immunology. Rigshospitalet. Copenhagen University Hospital)
Schidlowski, L. (Faculdades Pequeno Príncipe. Instituto de Pesquisa Pelé Pequeno Príncipe)
Prando, C. (Faculdades Pequeno Príncipe. Instituto de Pesquisa Pelé Pequeno Príncipe)
Condino-Neto, Antonio (Department of Immunology. Institute of Biomedical Sciences. University of São Paulo)
Cheikh, N. (Pediatric Hematology Unit. University Hospital of Besançon)
Bousfiha, A.A. (Department of Pediatric Infectious Disease and Clinical Immunology. CHU Ibn Rushd and LICIA. Laboratoire d'Immunologie Clinique. Inflammation et Allergie. Faculty of Medicine and Pharmacy. Hassan II University)
Bakkouri, J.E. (Laboratory of Immunology. CHU Ibn Rushd and LICIA. Laboratoire d'Immunologie Clinique. Inflammation et Allergie. Faculty of Medicine and Pharmacy. Hassan II University)
Peterson, P. (Molecular Pathology. Institute of Biomedicine and Translational Medicine. University of Tartu)
Pujol, Aurora 1968- (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Lévy, R. (Pediatric Hematology-Immunology and Rheumatology Unit. Necker Hospital for Sick Children. Assistance Publique-Hˆopitaux de Paris (AP-HP))
Quartier, P. (Pediatric Hematology-Immunology and Rheumatology Unit. Necker Hospital for Sick Children. Assistance Publique-Hˆopitaux de Paris (AP-HP))
Vinh, D.C. (Infectious Disease Susceptibility Program. Research Institute. McGill University Health Centre)
Boisson, Bertrand (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University)
Béziat, V. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University)
Zhang, S.Y. (Paris Cité University. Imagine Institute)
Borghesi, A. (Neonatal Intensive Care Unit. Fondazione IRCCS Policlinico San Matteo)
Pession, A. (Pediatric Unit. IRCCS Azienda Ospedaliero-Universitaria di Bologna)
Andreakos, E. (Center for Clinical. Experimental Surgery and Translational Research. Biomedical Research Foundation of the Academy of Athens)
Marr, N. (Research Branch. Sidra Medicine)
Mentis, A.F.A. (University Research Institute of Maternal and Child Health and Precision Medicine. National and Kapodistrian University of Athens)
H.mogensen, T. (Dept. of Biomedicine. Aarhus University)
Rodríguez-Gallego, C. (Department of Clinical Sciences. University Fernando Pessoa Canarias)
Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Tillmann, V. (Dept. of Pediatrics. Institute of Clinical Medicine. University of Tartu)
Neven, B. (Pediatric Hematology-Immunology and Rheumatology Unit. Necker Hospital for Sick Children. Assistance Publique-Hˆopitaux de Paris (AP-HP))
Trouillet-Assant, S. (International Center of Research in Infectiology. Lyon University. INSERM U1111. CNRS UMR 5308. ENS. UCBL)
Brodin, P. (SciLifeLab. Department Of Women's and Children's Health. Karolinska Institutet)
Abel, Laurent (Paris Cité University. Imagine Institute)
Jouanguy, Emmanuelle (Paris Cité University. Imagine Institute)
Zhang, Q. (Paris Cité University. Imagine Institute)
Martinón-Torres, F. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Salas, A. (Unidade de Xenética. Departamento de Anatomía Patolóxica e Ciencias Forenses. Instituto de Ciencias Forenses. Facultade de Medicina. Universidade de Santiago de Compostela. and GenPop Research Group. Instituto de Investigaciones Sanitarias (IDIS). Hospital Clínico Universitario de Santiago)
Gómez-Carballa, A. (Facultade de Medicina. Unidade de Xenética. Instituto de Ciencias Forenses. Universidade de Santiago de Compostela. and GenPoB Research Group. IDIS. SERGAS)
Gonzalez-Granado, L.I. (Immunodeficiencies Unit. Hospital 12 de octubre. Research Institute Hospital 12 octubre)
Kisand, K. (Molecular Pathology. Department of Biomedicine. Institute of Biomedicine and Translational Medicine. University of Tartu)
Okada, S. (Department of Pediatrics. Graduate School of Biomedical and Health Sciences. Hiroshima University)
Puel, A. (Paris Cité University. Imagine Institute)
Cobat, Aurélie (Paris Cité University. Imagine Institute)
Casanova, Jean-Laurent (Necker Hospital for Sick Children & INSERM)
Aguilera-Albesa, Sergio (Complejo Hospitalario de Navarra)
AlKhater, Suzan (College of Medicine. Imam Abdulrahman Bin Faisal University)
Alkan, G. (Selcuk University. Faculty of Medicine)
Castagnoli, R. (Pediatric Clinic. Fondazione IRCCS Policlinico San Matteo)
Cyrus, C. (Imam Abdulrahman Bin Faisal University (Dammam, Aràbia Saudí). Department of Biochemistry. College of Medicine)
Bozdemir, S.E. (Bursa City Hospital)
Emiroglu, M. (Selcuk University. Faculty of Medicine)
Gulhan, Belgin (Ankara City Hospital. Children's Hospital)
Erdeniz, E.H. (Ondokuz Mayıs University. Faculty of Medicine)
Hatipoglu, N. (Pediatric Infectious Diseases Unit. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. University of Health Sciences)
Bayhan, G.I. (Yildirim Beyazit University. Faculty of Medicine. Ankara City Hospital. Children's Hospital)
Jabandziev, P. (Department of Pediatrics. University Hospital Brno. Faculty of Medicine. Masaryk University)
Yuksek, S.K. (Health Science University Ankara City Hospital)
Karbuz, A. (Cemil Tascıoglu City Hospital)
Öz, Ş.K.T. (Selcuk University. Faculty of Medicine)
Marseglia, G.L. (Pediatric Clinic. Fondazione IRCCS Policlinico San Matteo)
Akcan, O.M. (Necmettin Erbakan University. Meram Medical Faculty)
Kılıç, A.O. (Necmettin Erbakan University. Meram Medical Faculty)
Parlakay, A.O. (Ankara City Hospital. Children's Hospital)
Papadaki, M. (Center for Clinical. Experimental Surgery and Translational Research. Biomedical Research Foundation of the Academy of Athens)
Slaba, K. (Department of Pediatrics. University Hospital Brno. Faculty of Medicine. Masaryk University)
Sevketoglu, Esra (University of Health Sciences Bakırköy Dr. Sadi Konuk Training and Research Hospital (Istanbul, Turquia))
Valencia-Ramos, J. (Hospital Universitario de Burgos)
Yahşi, A. (Ankara City Hospital. Children's Hospital)
Tuala, C. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Urbieta, A.I.D. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Esteban, B.D. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Santalla, M.J.D. (Internal Medicine Service. Hospital Clínico Universitario de Santiago)
Pérez, C.F. (Preventive Medicine Unit. Hospital Clínico Universitario de Santiago)
Villaverde, J.F. (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Rodríguez, C.G. (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Allut, J.L.G. (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Vicente, L.G. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Vázquez, E.G. (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Carballa, A.G. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Rial, J.G. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Barcala, F.J.G. (Pneumology Service. Hospital Clínico Universitario de Santiago)
Liñares, B.G. (Preventive Medicine Unit. Hospital Clínico Universitario de Santiago)
Iglesias, P.L. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Massa, B.L. (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Fuentes, M.L. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Franco, M.L. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Lago, A.L. (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Cruz, D.N.D.l (Microbiology Service. Hospital Clínico Universitario de Santiago)
Masid, E.N. (Manager of the Health Care Area of Santiago de Compostela and Barbanza. Hospital Clínico Universitario de Santiago)
Devesa, J.B.O. (Clinical Chemistry Laboratory. Hospital Clínico Universitario de Santiago)
Seco, J.P. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Núñez, M.P. (Internal Medicine Service. Hospital Clínico Universitario de Santiago)
Bernal, M.P.D.M. (Microbiology Service. Hospital Clínico Universitario de Santiago)
Freixo, H.P. (Preventive Medicine Unit. Hospital Clínico Universitario de Santiago)
Rodríguez, L.P. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Pischedda, S. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Romero, M.P. (Pharmaceutical Delivery. Training. Teaching. Research and Innovation. Hospital Clínico Universitario de Santiago)
Reino, A.P. (Internal Medicine Service. Hospital Clínico Universitario de Santiago)
Hervella, G.M.P. (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Verdes, T.Q. (Preventive Medicine Unit. Hospital Clínico Universitario de Santiago)
Collazo, L.R. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Casuso, P.R. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
García, S.R. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Vázquez, S.R. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Blanco, V.R. (Pneumology Service. Hospital Clínico Universitario de Santiago)
Calle, I.R. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Velasco, C.R. (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Núñez, N.R. (Pneumology Service. Hospital Clínico Universitario de Santiago)
Sánchez, C.R.T. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Paz, E.S. (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Orayyou, J.M.S. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Villanueva, C.S. (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Fernández, S.S. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Sanmartín, P.S. (Preventive Medicine Unit. Hospital Clínico Universitario de Santiago)
Muñiz, M.T. (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Pena, R.T. (Microbiology Service. Hospital Clínico Universitario de Santiago)
Castellano, M.T. (Microbiology Service. Hospital Clínico Universitario de Santiago)
Cuadrado, L.V. (Pneumology Service. Hospital Clínico Universitario de Santiago)
García, P.V. (Internal Medicine Service. Hospital Clínico Universitario de Santiago)
Iglesias, M.S.V. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Lasheras, S.V. (Translational Pediatrics and Infectious Diseases. Pediatrics Department. Hospital Clínico Universitario de Santiago. GENVIP Research Group. Instituto de Investigación Sanitaria de Santiago. Universidad de Santiago de Compostela)
Ferreiro-Iglesias, R. (Digestive Service. Hospital Clínico Universitario de Santiago)
Bastón-Rey, I. (Digestive Service. Hospital Clínico Universitario de Santiago)
Calviño-Suárez, C. (Digestive Service. Hospital Clínico Universitario de Santiago)
Aiuti, Alessandro (San Raffaele Telethon Institute for Gene Therapy. IRCCS Ospedale San Raffaele. Vita Salute San Raffaele University)
Al-Muhsen, S. (Immunology Research Lab. Department of Pediatrics. College of Medicine. King Saud University)
Al-Mulla, F. (Dasman Diabetes Institute. Department of Genetics and Bioinformatics)
Amara, A. (Laboratory of Genomes & Cell Biology of Disease. INSERM U944. CNRS UMR 7212. Université de Paris. Institut de Recherche Saint-Louis. Hôpital Saint-Louis)
Anderson, M.S. (Diabetes Center. University of California San Francisco)
Arias, A.A. (School of Microbiology. University of Antioquia UdeA)
Arkin, L.M. (Department of Dermatology. School of Medicine and Public Health. University of Wisconsin-Madison)
Feldman, H.B. (The Genetics Institute. Tel Aviv Sourasky Medical Center and Faculty of Medicine. Tel Aviv University)
Biggs, C.M. (Department of Pediatrics. BC Children's and St. Paul's Hospitals. University of British Columbia)
Bogunovic, Dusan (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Bolze, Alexandre (Helix)
Bondarenko, A. (International European University)
Bryceson, Y. (Department of Medicine. Center for Hematology and Regenerative Medicine. Karolinska Institutet)
Butte, M.J. (Division of Immunology. Allergy. and Rheumatology. Department of Pediatrics and the Department of Microbiology. Immunology. and Molecular Genetics. University of California)
Casari, G. (Clinical Genomics. IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University)
Christodoulou, J. (Murdoch Children's Research Institute and Department of Paediatrics. University of Melbourne)
Constantinescu, S.N. (de Duve Institute. UC Louvain and Ludwig Cancer Research)
Cooper, M.A. (Washington University School of Medicine)
Dalgard, C.L. (Department of Anatomy. Physiology & Genetics. Uniformed Services University of the Health Sciences)
Desai, M. (Bai Jerbai Wadia Hospital for Children)
Drolet, B.A. (School of Medicine and Public Health. University of Wisconsin)
Duval, X. (Inserm CIC 1425)
Baghdadi, J.E. (Genetics Unit. Military Hospital Mohamed V)
Eloy, P. (Hôpital Bichat)
Espinosa-Padilla, S. (Instituto Nacional de Pediatria (National Institute of Pediatrics))
Fellay, Jacques (School of Life Sciences. Ecole Polytechnique Fédérale de Lausanne. Precision Medicine Unit. Lausanne University Hospital and University of Lausanne)
Flores, Carlos (Faculty of Health Sciences. University Fernando Pessoa Canarias)
Franco, J.L. (Group of Primary Immunodeficiencies. University of Antioquia UDEA)
Froidure, A. (Institut de Recherche Expérimentale et Clinique (IREC). Université Catholique de Louvain)
Gorochov, G. (Sorbonne Université. Inserm. Centre d'Immunologie et des Maladies Infectieuses-Paris (CIMI PARIS). Assistance Publique-Hôpitaux de Paris (AP-HP) Hôpital Pitié-Salpêtrière)
Gregersen, P.K. (Feinstein Institute for Medical Research. Northwell Health USA)
Grimbacher, B. (Center for Chronic Immunodeficiency & Institute for Immunodeficiency. Medical Center. Faculty of Medicine. University of Freiburg)
Hagin, D. (The Genetics Institute Tel Aviv Sourasky Medical Center)
Halwani, R. (Immunology Research Lab. College of Medicine. King Saud University)
Heath, J.R. (Institute for Systems Biology)
Hsieh, E.W.Y. (Departments of Pediatrics. Immunology and Microbiology. University of Colorado. School of Medicine)
Husebye, E. (Haukeland University Hospital (Bergen, Noruega))
Imai, K. (Department of Community Pediatrics. Perinatal and Maternal Medicine. Tokyo Medical and Dental University (TMDU))
Itan, Yuval (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Jarvis, E.D. (Laboratory of Neurogenetics of Language and Howard Hughes Medical Institute. The Rockefeller University)
Kaja, E. (Department of Medical Chemistry and Laboratory Medicine. Poznan University of Medical Sciences)
Karamitros, T. (Bioinformatics and Applied Genomics Unit. Hellenic Pasteur Institute)
Ku, C.L. (Center for Molecular and Clinical Immunology. Chang Gung University)
Lau, Y.L. (Department of Paediatrics & Adolescent Medicine. The University of Hong Kong)
Ling, Y. (Shanghai Public Health Clinical Center. Fudan University)
Lucas, C.L. (Department of Immunobiology. Yale University School of Medicine)
Mansouri, D. (Department of Clinical Immunology and Infectious Diseases. National Research Institute of Tuberculosis and Lung Diseases. The Clinical Tuberculosis and Epidemiology Research Center. National Research Institute of Tuberculosis and Lung Diseases (NRITLD). Masih Daneshvari Hospital. Shahid Beheshti. University of Medical Sciences)
Maródi, L. (Primary Immunodeficiency Clinical Unit and Laboratory. Department of Dermatology. Venereology and Dermatooncology. Semmelweis University)
Mentré, F. (Hôpital Bichat)
Milner, J.D. (Department of Pediatrics. Columbia University Irving Medical Center)
Mironska, K. (University Clinic for Children's Diseases. Department of Pediatric Immunology. Medical Faculty. University " St.Cyril and Methodij" Skopje)
Mogensen, T.H. (Department of Biomedicine. Aarhus University)
Ng, L.F.P. (Lee Kong Chian School of Medicine. Nanyang Technology University)
Notarangelo, L.D. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica))
Novelli, A. (Laboratory of Medical Genetics. IRCCS Bambino Gesù Children's Hospital)
Novelli, G. (Department of Biomedicine and Prevention. Tor Vergata University of Rome)
O'Farrelly, C. (Comparative Immunology Group. School of Biochemistry and Immunology. Trinity Biomedical Sciences Institute. Trinity College Dublin)
Okamoto, K. (Tokyo Medical and Dental University)
Pape, J.W. (Haitian Study Group for Kaposi's Sarcoma and Opportunistic Infections (GHESKIO))
Perez de Diego, Rebeca (Instituto de Investigación Sanitaria del Hospital Universitario La Paz (Madrid))
Perez-Tur, J. (Instituto de Biomedicina de Valencia (IBV-CSIC))
Perlin, D.S. (Center for Discovery and Innovation. Hackensack Meridian Health)
Pesole, G. (Department of Biosciences. Biotechnology and Environment. University of Bari A. Moro)
Planas, A.M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Quintana-Murci, L. (Human Genomics and Evolution. Collège de France)
Ramaswamy, S. (Al Jalila Children's Hospital)
Renia, L. (Lee Kong Chian School of Medicine. Nanyang Technology University)
Resnick, I. (University Hospital St. Marina)
Sancho-Shimizu, V. (Centre for Paediatrics and Child Health. Faculty of Medicine. Imperial College London)
Sediva, A. (Department of Immunology. Second Faculty of Medicine Charles University. V Uvalu. University Hospital in Motol)
Seppänen, M.R.J. (Rare Diseases Center and Pediatric Research Center. Children's Hospital. University of Helsinki and Helsinki University Hospital)
Shahrooei, M. (Dr. Shahrooei Lab)
Shcherbina, A. (Department of Immunology. Dmitry Rogachev National Medical Research Center of Pediatric Hematology. Oncology and Immunology)
Slaby, O. (Central European Institute of Technology & Department of Biology. Faculty of Medicine. Masaryk University)
Snow, A.L. (Department of Pharmacology & Molecular Therapeutics. Uniformed Services University of the Health Sciences)
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron)
Soumelis, V. (AP-HP. Hôpital Saint-Louis. Laboratoire d'Immunologie)
Spaan, A.N. (Department of Medical Microbiology. University Medical Center Utrecht)
Su, H.C. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica))
Tangye, S.G. (St Vincent's Clinical School. Faculty of Medicine. UNSW)
Tayoun, A.A. (Al Jalila Children's Hospital)
Temel, Ş.G. (Department of Translational Medicine. Health Sciences Institute. Bursa Uludağ University)
Thorball, C. (Precision Medicine Unit. Lausanne University Hospital and University of Lausanne)
Tiberghien, P. (Etablissement Francais Du Sang. La Plaine-Saint Denis)
Turvey, S.E. (BC Children's Hospital (Canadà))
Uddin, K.M.F. (Centre for Precision Therapeutics. Genetics & Genomic Medicine Centre. NeuroGen Children's Healthcare and Lecturer. Holy Family Red Crescent Medical College Dhaka)
Uddin, M.J. (Cellular Intelligence (Ci) Lab. GenomeArc Inc.)
Beek, D.v.d (Department of Neurology. Amsterdam Neuroscience. Amsterdam University Medical Center. University of Amsterdam)
Bernuth, H.v (Berlin Institutes of Health (BIH). Berlin-Brandenburg Center for Regenerative Therapies)
Wauters, J. (Department of General Internal Medicine. Medical Intensive Care Unit. University Hospitals Leuven)
Zatz, Mayana (Biosciences Institute. University of São Paulo)
Zawadzki, Pawel (Molecular Biophysics Division. Faculty of Physics. A. Mickiewicz University)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	We found that 19 (10. 4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3. 8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6. 6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0. 2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67. 6 [5. 7-9,196. 6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2. 6 [1. 2-5. 3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12. 9 [4. 6-35. 9]) than for those neutralizing low concentrations (OR [95% CI] = 5. 5 [3. 1-9. 6]) of IFN-ω and/or IFN-α2.
Grants:	Instituto de Salud Carlos III PI21/01642 Instituto de Salud Carlos III PI22/00162 Instituto de Salud Carlos III PI19/01039 Ministerio de Economía y Competitividad PI16/01569 Instituto de Salud Carlos III PI19/01090 Instituto de Salud Carlos III PI22/00406 Ministerio de Economía y Competitividad PI16/00759 Instituto de Salud Carlos III PI18/00223 Instituto de Salud Carlos III PI19/00208 Instituto de Salud Carlos III PI20/00876 Instituto de Salud Carlos III PI21/00211 Agencia Estatal de Investigación RTC-2017-6471-1
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	The journal of experimental medicine, Vol. 221 Núm. 2 (january 2024) , p. e20231353, ISSN 1540-9538

DOI: 10.1084/jem.20231353
PMID: 38175961

45 p, 6.2 MB

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