Towards a tailored approach for patients with acute diverticulitis and abscess formation. The DivAbsc2023 multicentre case-control study
Podda, Mauro (University of Cagliari)
Ceresoli, Marco (Milano-Bicocca University)
Di Martino, Marcello (Università del Piemonte Orientale)
Ortenzi, Monica (Polytechnic University of Marche)
Pellino, Gianluca (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Pata, Francesco (University of Calabria)
Ielpo, Benedetto (Hospital del Mar (Barcelona, Catalunya))
Murzi, Valentina (University of Cagliari)
Balla, Andrea (IRCCS San Raffaele Scientific Institute)
Lepiane, Pasquale (Hospital "San Paolo", Civitavecchia)
Tamini, Nicolò (Milano-Bicocca University)
De Carlo, Giulia (Milano-Bicocca University)
Davolio, Alessia (Milano-Bicocca University)
Di Saverio, Salomone (Madonna del Soccorso Hospital)
Cardinali, Luca (Madonna del Soccorso Hospital)
Botteri, Emanuele (General Surgery Unit, ASST Spedali Civili, Montichiari)
Vettoretto, Nereo (General Surgery Unit, ASST Spedali Civili, Montichiari)
Gelera, Pier Paolo (General Surgery Unit, ASST Spedali Civili, Montichiari)
De Simone, Belinda (Poissy and Saint-Germain-en-Laye Hospitals (Poissy, França))
Grasso, Antonella (University of L'Aquila)
Clementi, Marco (University of L'Aquila)
Meloni, Danilo (University of L'Aquila)
Poillucci, Gaetano (S. Matteo Degli Infermi Hospital)
Favi, Francesco (Bufalini Hospital)
Rizzo, Roberta (Bufalini Hospital)
Montori, Giulia (ULSS2 Marca Trevigiana (Treviso, Itàlia). Department of General Surgery)
Procida, Giuseppa (ULSS2 Marca Trevigiana (Treviso, Itàlia). Department of General Surgery)
Recchia, Irene (ULSS2 Marca Trevigiana (Treviso, Itàlia). Department of General Surgery)
Agresta, Ferdinando (ULSS2 Marca Trevigiana (Treviso, Itàlia). Department of General Surgery)
Virdis, Francesco ("Niguarda Ca Granda" Hospital)
Cioffi, Stefano Piero Bernardo ("Niguarda Ca Granda" Hospital)
Pellegrini, Martina ("Niguarda Ca Granda" Hospital)
Sartelli, Massimo (Macerata Hospital)
Coccolini, Federico (Pisa University Hospital)
Catena, Fausto (ULSS2 Marca Trevigiana, Vittorio Veneto)
Pisanu, Adolfo (University of Cagliari)

Date:	2024
Abstract:	This multicentre case-control study aimed to identify risk factors associated with non-operative treatment failure for patients with CT scan Hinchey Ib-IIb and WSES Ib-IIa diverticular abscesses. This study included a cohort of adult patients experiencing their first episode of CT-diagnosed diverticular abscess, all of whom underwent initial non-operative treatment comprising either antibiotics alone or in combination with percutaneous drainage. The cohort was stratified based on the outcome of non-operative treatment, specifically identifying those who required emergency surgical intervention as cases of treatment failure. Multivariable logistic regression analysis to identify independent risk factors associated with the failure of non-operative treatment was employed. Failure of conservative treatment occurred for 116 patients (27. 04%). CT scan Hinchey classification IIb (aOR 2. 54, 95%CI 1. 61;4. 01, P < 0. 01), tobacco smoking (aOR 2. 01, 95%CI 1. 24;3. 25, P < 0. 01), and presence of air bubbles inside the abscess (aOR 1. 59, 95%CI 1. 00;2. 52, P = 0. 04) were independent predictors of failure. In the subgroup of patients with abscesses > 5 cm, percutaneous drainage was not associated with the risk of failure or success of the non-operative treatment (aOR 2. 78, 95%CI − 0. 66;3. 70, P = 0. 23). Non-operative treatment is generally effective for diverticular abscesses. Tobacco smoking's role as an independent risk factor for treatment failure underscores the need for targeted behavioural interventions in diverticular disease management. IIb Hinchey diverticulitis patients, particularly young smokers, require vigilant monitoring due to increased risks of treatment failure and septic progression. Further research into the efficacy of image-guided percutaneous drainage should involve randomized, multicentre studies focussing on homogeneous patient groups.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Diverticular abscess ; Conservative treatment ; Non-operative treatment ; Failure ; Risk factors ; Percutaneous drainage
Published in:	Surgical endoscopy and other interventional techniques, Vol. 38, Num. 6 (June 2024) , p. 3180-3194, ISSN 1432-2218

DOI: 10.1007/s00464-024-10793-z
PMID: 38632117

15 p, 1.3 MB

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