The role of thrombophilias in reproduction: A swot analysis
Fabregues, Francisco (Hospital Clínic i Provincial de Barcelona)
García-Velasco, Juan A. (IVI RMA Madrid)
Llácer, Joaquín (Ginefiv-GeneraLife)
Requena, Antonio (Ginefiv-GeneraLife)
Checa, Miguel Angel (Parc de Salut MAR de Barcelona)
Bellver, José (Universitat de València)
Espinós, Juan José (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)

Fecha:	2023
Resumen:	Thrombophilia is a group of inherited or acquired coagulation disorders that have been associated with reproductive failure. However, there are still no clear recommendations on whether its inclusion in the initial study of the infertile couple or patients with recurrent implantation failure is necessary. In this discussion paper, based on a SWOT (strengths, weaknesses, opportunities, threats) analysis, the different aspects of the repercussions of thrombophilia screening and treatment in reproduction are evaluated. To avoid possible subjectivity in the analysis and results of this study, researchers followed Oxford criteria for the evaluation of evidence. The results from the evaluation of the reviewed bibliography seem to indicate that, pending new evidence, it would be advisable not to include thrombophilia screening in the initial baseline study of the infertile couple. There is no evidence to support a clear association between thrombophilia and implantation failure or infertility. Thrombophilia testing in this setting may increase cost, with minimal potential benefit and lead to inappropriate use of anticoagulants with possible deleterious adverse effects. Future well-designed studies are needed to assess the possible benefit of anticoagulant therapy in infertile thrombophilic patients with implantation failure.
Derechos:	Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió acceptada per publicar
Materia:	Anticoagulants ; Antiphospholipid syndrome ; Infertility ; Recurrent implantation failure ; Thrombophilia
Publicado en:	Eur J Obstet Gynecol Reprod Biol, Vol. 280 (January 2023) , p. 12-21, ISSN 0301-2115

DOI: 10.1016/j.ejogrb.2022.10.024

Postprint 36 p, 435.6 KB

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