The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO)
Pizarro, David (Hospital Universitario Ramón y Cajal (Madrid))
Romero, Ignacio (Spanish Group for Investigation on Ovarian Cancer (Madrid))
Pérez-Mies, Belén (Universidad Alcalá (Alcalá de Henares, Madrid))
Redondo Sánchez, Andrés (Universidad Autónoma de Madrid)
Caniego-Casas, Tamara (Instituto de Salud Carlos III)
Carretero-Barrio, Irene (Universidad Alcalá (Alcalá de Henares, Madrid))
Cristóbal, Eva (Instituto de Salud Carlos III)
Gutiérrez-Pecharromán, Ana (University Hospital Getafe)
Santaballa, Ana (Hospital Universitari i Politècnic La Fe (València))
D'Angelo, Emanuela (University "G.D'Annunzio" of Chieti-Pescara)
Hardisson, David (Hospital Universitario La Paz (Madrid))
Vieites, Begoña (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Matías-Guiu, Xavier (Hospital Universitari de Bellvitge)
Estévez-García, Purificación (Instituto de Biomedicina de Sevilla)
Guerra, Eva (Hospital Universitario Ramón y Cajal (Madrid))
Prat, Jaime (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques)
Poveda, Andrés (Hospital Quirón Salud (València))
López-Guerrero, J.A. (Spanish Group for Investigation on Ovarian Cancer (Madrid))
Palacios, José (Universidad Alcalá (Alcalá de Henares, Madrid))

Fecha:	2023
Resumen:	Early stages are under-represented in studies on the molecular and immune features of high-grade serous ovarian carcinoma (HGSOC), and specific studies focused on early-stage HGSOC are required for a better prognostic stratification and to personalize chemotherapy. The aim of this study was to determine the prognostic significance of CD8+ and CD4+ tumor-infiltrating lymphocytes (TILs), tumoral cell PD-L1 expression, BRCA mutational status and tumor mutation burden (TMB) in early-stage HGSOC. A retrospective study was performed on stage I and II HGSOC from the Molecular Reclassification of Early Stages of Ovarian Cancer (RECLAMO) cohort from the Spanish Group of Ovarian Cancer Research (GEICO). Centralized histological typing was performed based on morphological and immunohistochemical features. Intraepithelial (i) and stromal (s) CD8+ and CD4+ T cells and PD-L1 were evaluated on tissue microarrays by immunohistochemistry. BRCA1 and BRCA2 mutation status and TMB were analyzed in tumor DNA using next-generation sequencing. The study included 124 tumors. High iCD8+ (.
Ayudas:	Instituto de Salud Carlos III PI19/01331 Instituto de Salud Carlos III PI22/01892 Instituto de Salud Carlos III PMP22/00054 Ministerio de Economía y Competitividad CB16/12/00316 European Development Regional Fund 'A way to achieve Europe' (FEDER) CB16/12/00316 Spanish Group of Research in Ovarian Cancer (GEICO group) CB16/12/00316 Spanish Association Against Cancer Scientific Foundation (AECC) CB16/12/00316
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	High-grade serous ovarian carcinoma ; Early stage ; PD-L1 ; BRCA ; TMB
Publicado en:	International journal of molecular sciences, Vol. 24 (july 2023) , ISSN 1422-0067

DOI: 10.3390/ijms241311183
PMID: 37446361

15 p, 4.9 MB

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