| Home > Articles > Published articles > Interaction between Orexin-A and sleep quality in females in extreme weight conditions |
| Date: | 2016 |
| Description: | 20 pàg. |
| Abstract: | The current study examined the relationship between plasma orexin-A and sleep in obesity. Concentrations of orexin-A and sleep were evaluated in 26 obese, 40 morbid obese and 32 healthy-weight participants. The sleep monitor Actiwatch AW7 and the Pittsburgh Sleep Quality Index were used to evaluate sleep. The Symptom Checklist-90-Revised was administered to assess symptoms of psychopathology. A higher weight status was associated with elevated orexin-A levels (p = . 050), greater depression, anxiety and somatization symptoms (all: p < . 001), and impoverished self-reported sleep quality (p < . 001). A quadratic trend was found in objective sleep time, being longest in the obese group (p = . 031). Structural equation modeling showed plasma orexin-A to be related to poor total sleep quality, which in turn was associated with elevated body mass index. Our data confirm an interaction between elevated plasma orexinA concentrations and poor sleep that contributes to fluctuations in body mass index. |
| Grants: | Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1672 Ministerio de Economía y Competitividad PSI2014-56303-REDT |
| Note: | Altres ajuts: This manuscript was partially supported by grants from Institutode Salud Carlos III (FIS PI14/290 and CIBEROBNn) and FondoEuropeo de Desarrollo Regional (FEDER) a way to build Europe. Sarah Sauchelli is recipient of a pre-doctoral Grant (2013-17) byIDIBELL. José C. Fernández-García is recipient of a research con-tract from Servicio Andaluz de Salud (SAS) (B-0033-2014).Lourdes Garrido-Sánchez is supported by a fellowship from theFondo de Investigación Sanitaria (FIS) 'Miguel Servet I'CP13/00188. |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió acceptada per publicar |
| Subject: | Body mass index ; Obesity ; Orexin ; Sleep |
| Published in: | European eating disorders review, Vol. 24 Núm. 6 (2016) , p. 510-517, ISSN 1099-0968 |
Postprint 20 p, 471.5 KB |