Eptinezumab for the preventive treatment of episodic and chronic migraine : a narrative review
Irimia, Pablo (Clínica Universidad de Navarra)
Santos Lasaosa, Sonia (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Pozo-Rosich, Patricia (Universitat Autònoma de Barcelona. Departament de Medicina)
Leira, Rogelio (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Pascual Gómez, Julio (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Lainez Andres, Jose Miguel (Universidad Católica de Valencia)

Date:	2024
Abstract:	Eptinezumab, a monoclonal antibody that targets calcitonin gene-related peptide (CGRP), was recently approved in Europe for the prophylactic treatment of migraine in adults who have at least four migraine days a month. Eptinezumab is administered by intravenous infusion every 12 weeks. During recent months, a considerable amount of evidence from eptinezumab trials has been published. The aim of this review is to describe the existing evidence on the tolerability, safety and efficacy of eptinezumab in patients with migraine. Data from randomized (PROMISE-1, PROMISE-2, RELIEF and DELIVER) and open-label (PREVAIL) phase 3 clinical trials have demonstrated the favorable effect of eptinezumab in migraine symptoms from first day of treatment. These studies showed that eptinezumab results in an overall reduction in mean monthly migraine days (MMDs), increases in the ≥50% and ≥ 75% migraine responder rates (MRRs) and improvements in patient-reported outcome measures in both patients with episodic migraine (EM) and with chronic migraine (CM), including patients who failed previous preventive treatments. The RELIEF trial also showed that eptinezumab, within 2 h of administration, reduced headache pain, migraine-associated symptoms and acute medication use when administered during a migraine attack. Eptinezumab benefits manifested as early as day 1 after dosing and with the subsequent doses lasted up to at least 2 years. Treatment-emergent adverse events reported by ≥2% of patients included upper respiratory tract infection and fatigue. Current evidence demonstrates that eptinezumab has a potent, fast-acting, sustained migraine preventive effect in patients with EM and CM. Eptinezumab has also shown to be well tolerated, supporting its use in the treatment of patients with migraine and inclusion in the current migraine therapeutic options.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Eptinezumab ; Clinical development ; Narrative review ; Chronic migraine ; Episodic migraine ; Preventive treatment ; Calcitonin gene-related peptide ; Fast onset of action
Published in:	Frontiers in neurology, Vol. 15 (March 2024) , ISSN 1664-2295

DOI: 10.3389/fneur.2024.1355877
PMID: 38523607

14 p, 1.6 MB

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