Synaptic dysfunction induced by Aβ oligomers in Alzheimer's disease: AKAP150-NFAT signalling as a molecular target
Román, Elena Ortiz de Zárate
Rodríguez Álvarez, José, dir.
Miñano Molina, Alfredo Jesús (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Universitat Autònoma de Barcelona. Facultat de Biociències

Fecha:	2025
Descripción:	31 pag.
Resumen:	Alzheimer's disease (AD) is the most common form of dementia worldwide and to this day no effective cure has been found. Various studies suggest that synaptic dysfunction is one of the earliest pathological events in this disease, preceding even clinical symptoms. In this regard, soluble amyloid-beta oligomers (Aβo) have been identified as neurotoxic compounds that can alter synaptic function. The aim of this study is to investigate the molecular effects of Aβo on some key components of the postsynaptic signalling complex in hippocampal neuronal cultures, focusing on the AKAP-CaN-NFAT.
Resumen:	signalling pathway, which includes scaffolding protein AKAP79/150, phosphatase calcineurin (CaN) and transcription factor NFATc3. In this research, we observed that.
Resumen:	Aβo reduce the expression of AKAP150 in a time-dependent manner. This reduction was not prevented by the blocking of L-type calcium channels (LTCCs), suggesting that LTCCs are not involved in Aβo-induced AKAP150 decrease. Additionally, Aβo alter the cellular localization of NFATc3 and modify dendritic distribution. Collectively, these results suggest that Aβo trigger time-dependent dynamic alterations in the AKAP-CaNNFAT complex, potentially disrupting postsynaptic organization and affecting geneexpression. Our findings support the understanding of early molecular mechanisms that.
Resumen:	contribute to synaptic dysfunction in AD and open the possibility of identifying these compounds as therapeutical targets.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre i quan aquestes es distribueixin sota la mateixa llicència que regula l'obra original i es reconegui l'autoria.
Lengua:	Anglès
Titulación:	Bioquímica, Biologia Molecular i Biomedicina [4313794]
Plan de estudios:	Màster Universitari en Bioquímica, Biologia Molecular i Biomedicina [1599]
Documento:	Treball de fi de postgrau
Materia:	Malaltia d'Alzheimer ; Oligòmers de beta-amiloide ; AKAP79/150 ; NFATc3 ; Calcineurina ; Canals de calci tipus L ; Disfunció sinàptica ; Enfermedad de Alzheimer ; Oligómeros de beta-amiloide ; Canales de calcio tipo ; Disfunción sináptica ; Alzheimer's disease ; Amyloid-beta oligomers ; Calcineurin ; L-type calcium channels ; Synaptic dysfunction

32 p, 1.7 MB

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