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| Home > Articles > Published articles > Sex differences in psychosocial functioning and neurocognition in bipolar disorder : |
(Hospital Clínic i Provincial de Barcelona) (Universitat de Barcelona) (Universitat de Barcelona) (Universitat de Barcelona) (Universitat de Barcelona) (Universitat de Barcelona) (Universitat de Barcelona) (Universitat de Barcelona) (Universitat de Barcelona) (Mental Health Center of Perugia) (University of Perugia) (Universitat de Barcelona) (Hospital Universitari Vall d'Hebron. Institut de Recerca) (Universitat de Barcelona) (Universitat de Barcelona) (Hospital Universitari Vall d'Hebron. Institut de Recerca) (Universitat de Barcelona)| Date: | 2025 |
| Abstract: | Impairment in both psychosocial functioning and neurocognition (NC) performance is present in bipolar disorder (BD) yet the role of sex differences in these deficits remains unclear. The present systematic review and meta-analysis examined whether males and females with BD demonstrate differences in psychosocial functioning and NC performance. The Cochrane Library, EMBASE, PsycINFO, PubMed, Scopus, and Web of Science databases were systematically searched from inception until November 20, 2023. Twenty studies published between 2005 and 2023 with a total sample size of 2286 patients with BD were included. A random effects meta-analysis revealed a statistically significant result with a small effect (SMD = 0. 313) for sex differences in verbal learning and memory as well as visual learning and memory (SMD = 0. 263). Females outperformed males in both domains. No significant sex differences were observed for any other NC outcome or psychosocial functioning. High heterogeneity and differences in assessment scales used should be considered when interpreting these findings, given their potential impact on results. Future research should adopt a more homogenous, standardized approach using longitudinal designs to gain a clearer insight into sex differences in this population. This approach so may increase the use of preventative therapeutic options to address the difficult clinical challenge of reaching cognitive and functional recovery. |
| Grants: | Instituto de Salud Carlos III PI18/00805 Instituto de Salud Carlos III PI21/00787 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-1358 Instituto de Salud Carlos III PI21/00340 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-135 Instituto de Salud Carlos III PI18/00789 Instituto de Salud Carlos III PI21/00787 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1365 Fundació la Marató de TV3 202234-32 Fundació la Marató de TV3 202234-30 Fundació la Marató de TV3 202205-10 Instituto de Salud Carlos III PI17/01066 Instituto de Salud Carlos III PI20/00344 Instituto de Salud Carlos III PI21/00787 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Bipolar disorder ; Meta-analysis ; Neurocognition ; Psychosocial functioning ; Sex |
| Published in: | European psychiatry, Vol. 68 (march 2025) , ISSN 1778-3585 |
