The NEuroCOUGH Chronic Cough Registry : a protocol for a pan-European observational study
Cho, Peter S.P. (King's College London)
Birring, Surinder S. (King's College London)
McDowell, Clíona (Northern Ireland Clinical Research Network)
Brown, Tony (Northern Ireland Clinical Research Network)
Hull, James H. (University College London)
Smith, Jaclyn A. (The University of Manchester)
Guilleminault, Laurent (Toulouse University Hospital)
Kardos, Peter (Red Cross Maingau Hospital (Frankfurt, Alemanya))
van den Berg, Jan (Isala Hospital (Zwolle, Holanda))
Domingo, Christian (Universitat Autònoma de Barcelona. Departament de Medicina)
Marsden, Paul (Manchester University NHS Foundation Trust)
Idzko, Marco (University Hospital Vienna AKH)
Lavorini, Federico (Università degli Studi di Firenze)
Martin, Matthew J. (Nottingham University Hospitals NHS Trust (Regne Unit))
Slinger, Claire (Lancashire Teaching Hospitals NHS Trust (Preston, Regne Unit))
Demoulin-Alexikova, Silvia (Université de Lille)
Stolz, Daiana (University of Freiburg)
Michels, Arent Jan (Anna Hospital (Geldrop, Holanda))
Tirzite, Madara (Riga East University Hospital)
Gradauskiene, Brigita (Lithuanian University of Health Sciences)
Winck, Joao Carlos (Universidade do Porto)
Emilsson, Ossur Ingi (University of Iceland (Reykjavik, Islàndia))
Kaltsakas, Georgios (King's College London)
Hyldgaard, Charlotte (University Clinic for Innovative Patient Pathways (Viborg, Dinamarca))
Chung, Kian Fan (Imperial College London (London, Regne Unit))
Millqvist, Eva (University of Gothenburg)
Narayanan, Ajit (Auckland University of Technology)
Gossage, Lisa (Auckland University of Technology)
Buchwald-Mackintosh, Khan (Auckland University of Technology)
Siegert, Richard J. (Auckland University of Technology)
Schulte, Marianne (UZ Leuven)
Nair, Abitha (Belfast City Hospital (Belfast, Irlanda))
Nelson, Jemma (Northumbria Healthcare NHS Foundation Trust (North Shields, Regne Unit))
Parker, Sean M. (North Tyneside General Hospital, Northumbria Healthcare NHS Foundation Trust (North Shields, Regne Unit))
Dąbrowska, Marta (Medical University of Warsaw)
Morice, Alyn (University of Hull)
Dupont, Lieven J.A. (Katholieke Universiteit te Leuven (1970- ))
McGarvey, Lorcan (Queen's University Belfast)

Fecha:	2025
Resumen:	Chronic cough is a common clinical problem which is burdensome for patients and can be difficult to treat. Individual centres of cough expertise have been set up in countries across Europe but to date there has been no means to collate and analyse clinical data from such sites to gain a more comprehensive understanding of cough phenotypes, disease burden and the natural history of this condition. The NEw Understanding in the tReatment Of COUGH (NEuroCOUGH) registry is the first pan-European prospective observational study of adult patients referred for evaluation of chronic cough. Patients (≥18 years old) with a cough lasting more than 8 weeks with no chest radiology findings to explain the cough will be recruited. Key exclusion criteria include current or recent (<12 months) smoking, significant smoking history (≥20 pack-years) and obstructive spirometry (forced expiratory volume in 1 s/forced vital capacity ratio <0. 6). The study aims to recruit 2500 patients across 13 European sites by 2026 and participants will be followed up at 12-monthly intervals for 36 months. The registry comprises comprehensive clinical, physiological and biological data on chronic cough, along with data on the impact and longitudinal outcome of chronic cough. The NEuroCOUGH registry has been established at a time of considerable advance in the field of cough. It will serve as a valuable clinical and research resource which will extend our current understanding of this difficult to treat condition. The initiative is also intended to encourage the establishment of new specialist cough clinics, thus creating much needed clinical trial infrastructure throughout Europe to ultimately improve patient care. The ERS NEuroCOUGH CRC Chronic Cough Registry is the first multicentre European observational study comprising clinical, physiological, biological and outcome data to provide insight on phenotypes and endotypes of chronic cough to improve patient care.
Ayudas:	European Respiratory Society Clinical Research Collaboration
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	ERJ Open Research, Vol. 11 (september 2025) , ISSN 2312-0541

DOI: 10.1183/23120541.00289-2025
PMID: 40989779

10 p, 1.1 MB

El registro aparece en las colecciones:
Artículos > Artículos de investigación
Artículos > Artículos publicados