On equivalence and bioequivalence testing
Ocaña, Jordi (Universitat de Barcelona)
Sánchez, M. Pilar (Universidad de Chile)
Sánchez, Álex (Universitat de Barcelona)
Carrasco, Josep Lluís (Universitat de Barcelona)

Date: 2008
Abstract: Equivalence testing is the natural approach to many statistical problems. First, its main application, bioequivalence testing, is reviewed. The basic concepts of bioequivalence testing (2×2 crossover designs, TOST, interval inclusion principle, etc. ) and its problems (TOST biased character, the carryover problem, etc. ) are considered. Next, equivalence testing is discussed more generally. Some applications and methods are reviewed and the relation of equivalence testing and distance-based inference is highlighted. A new distance-based method to determine whether two gene lists are equivalent in terms of their annotations in the Gene Ontology illustrates these ideas. We end with a general discussion and some suggestions for future research.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Crossover designs ; TOST ; Intersection-union ; Distance-based inference ; Validation of simulation models ; Gene Ontology
Published in: SORT : statistics and operations research transactions, Vol. 32, Núm. 2 (July-December 2008) , p. 151-176, ISSN 1696-2281

Adreça original: http://www.raco.cat/index.php/SORT/article/view/144068

26 p, 533.1 KB

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 Record created 2012-07-25, last modified 2017-06-21

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