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Big data and reference intervals : rationale, current practices, harmonization and standardization prerequisites and future perspectives of indirect determination of reference intervals using routine data / Martínez Sánchez, Luisa María (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Marques-Garcia, Fernando (University Hospital of Salamanca. Department of Clinical Biochemistry) ; Ozarda, Yesim (Uludag University School of Medicine. Department of Medical Biochemistry) ; Blanco, Albert (Hospital Universitari Vall d'Hebron) ; Brouwer, Nannette (Diagnost-IQ, Expert Centre for Clinical Chemistry) ; Canalias Reverter, Francesca (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Cobbaert, Christa (Leiden University Medical Centre. Department of Clinical Chemistry and Laboratory Medicine) ; Thelen, Marc (Stichting Kwaliteitsbewaking Medische Laboratoriumdiagnostiek) ; den Elzen, Wendy (Leiden University Medical Centre. Department of Clinical Chemistry and Laboratory Medicine)
Reference intervals are commonly used as a decision-making tool. In this review, we provide an overview on "big data" and reference intervals, describing the rationale, current practices including statistical methods, essential prerequisites concerning data quality, including harmonization and standardization, and future perspectives of the indirect determination of reference intervals using routine laboratory data.
2020 - DOI (Digital Object Identifier)

10.1515/almed-2020-0034
Advances in Laboratory Medicine, Vol. 2 (August 2020) , p. 9-16

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