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14 p, 1.7 MB Crown ethers reverse P-glycoprotein-mediated multidrug resistance in cancer cells / Guberovic, Iva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Marjanović, Marko (Ruđer Bošković Institute. Division of Molecular Medicine) ; Mioč, Marija (Ruđer Bošković Institute. Division of Molecular Medicine) ; Ester, Katja (Ruđer Bošković Institute. Division of Molecular Medicine) ; Martin-Kleiner, Irena (Ruđer Bošković Institute. Division of Molecular Medicine) ; Šumanovac Ramljak, Tatjana (Ruđer Bošković Institute. Department of Organic Chemistry and Biochemistry) ; Mlinarić-Majerski, Kata (Ruđer Bošković Institute. Department of Organic Chemistry and Biochemistry) ; Kralj, Marijeta (Ruđer Bošković Institute. Division of Molecular Medicine)
Multidrug resistance (MDR) is a widespread phenomenon exhibited by many cancers and represents a fundamental obstacle for successful cancer treatments. Tumour cells commonly achieve MDR phenotype through overexpression and/or increased activity of ABC transporters. [...]
2018 - 10.1038/s41598-018-32770-y
Scientific reports, Vol. 8 (september 2018)  

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