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21 p, 2.4 MB Selective brain entry of lipid nanoparticles in haemorrhagic stroke is linked to biphasic blood-brain barrier disruption / Al-Ahmady, Zahraa S. (The University of Manchester. Nanomedicine Lab, Division of Pharmacy and Optometry) ; Dickie, Ben R. (University of Manchester. Geoffrey Jefferson Brain Research Centre) ; Aldred, Isabelle (The University of Manchester. Nanomedicine Lab, Division of Pharmacy and Optometry) ; Jasim, Dhifaf A. (The University of Manchester. Nanomedicine Lab, Division of Pharmacy and Optometry) ; Barrington, Jack (University of Manchester. Division of Neuroscience and Experimental Psychology) ; Haley, Michael J (University of Manchester. Division of Neuroscience and Experimental Psychology) ; Lemarchand, Eloise (University of Manchester. Division of Neuroscience and Experimental Psychology) ; Coutts, Graham (University of Manchester. Division of Neuroscience and Experimental Psychology) ; Kaur, Satinderdeep (Nottingham Trent University. Pharmacology Department) ; Bates, Jessica (Nottingham Trent University. Pharmacology Department) ; Curran, Sarah (Nottingham Trent University. Pharmacology Department) ; Goddard, Ruth (Nottingham Trent University. Pharmacology Department) ; Walker, Megan (Nottingham Trent University. Pharmacology Department) ; Parry-jones, Adrian (University of Manchester. Geoffrey Jefferson Brain Research Centre) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ; Allan, Stuart M. (University of Manchester. Geoffrey Jefferson Brain Research Centre)
Haemorrhagic stroke represents a significant public health burden, yet our knowledge and ability to treat this type of stroke are lacking. Previously we showed that we can target ischaemic-stroke lesions by selective translocation of lipid nanoparticles through the site of blood-brain barrier (BBB) disruption. [...]
2022 - 10.7150/thno.72167
Theranostics, Vol. 12, Issue 10 (May 2022) , p. 4477-4497  
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