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TP53 Abnormalities Are Underlying the Poor Outcome Associated with Chromothripsis in Chronic Lymphocytic Leukemia Patients with Complex Karyotype / Ramos-Campoy, Silvia (Institut Hospital del Mar d'Investigacions Mèdiques) ; Puiggros, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ; Kamaso, Joanna (Institut Hospital del Mar d'Investigacions Mèdiques) ; Beà, Sílvia (Centro de Investigación Biomédica en Red de Cáncer) ; Bougeon, Sandrine (Lausanne University Hospital) ; Larráyoz, María José (Universidad Pública de Navarra) ; Costa, Dolors (Centro de Investigación Biomédica en Red de Cáncer) ; Parker, Helen (University of Southampton) ; Rigolin, Gian Matteo (St. Anna University Hospital) ; Blanco, María Laura (Institut d'Investigació Biomèdica Sant Pau) ; Collado, Rosa (Consorcio Hospital General Universitario) ; Ancín, Idoya (Hospital Universitario de Cruces (Barakaldo, País Basc)) ; Salgado, Rocío (Fundación Jiménez Díaz) ; Moro-García, Marco A. (Hospital Universitario Central de Asturias) ; Baumann, Tycho (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Gimeno, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ; Moreno, Carol (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Salido, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ; Calvo, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ; Calasanz, M.J (Universidad Pública de Navarra) ; Cuneo, Antonio (Hematology Section. St. Anna University Hospital) ; Nguyen-Khac, Florence (Sorbonne University) ; Oscier, David (Royal Bournemouth Hospital) ; Haferlach, Claudia (MLL Munich Leukemia Laboratory) ; Strefford, Jonathan C (University of Southampton) ; Schoumans, Jacqueline (Lausanne University Hospital) ; Espinet, Blanca (Institut Hospital del Mar d'Investigacions Mèdiques) ; Universitat Autònoma de Barcelona
Chromothripsis (cth) has been associated with a dismal outcome and poor prognosis factors in patients with chronic lymphocytic leukemia (CLL). Despite being correlated with high genome instability, previous studies have not assessed the role of cth in the context of genomic complexity. [...]
2022 - DOI (Digital Object Identifier)

10.3390/cancers14153715
Cancers, Vol. 14 Núm. 15 (august 2022) , p. 3715

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