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10 p, 344.1 KB Markers of early changes in cognition across cohorts of adults with down syndrome at risk of alzheimer's disease / Aschenbrenner, A.J. (Washington University in St. Louis. Department of Neurology) ; Asaad Baksh, R. (The London Down Syndrome (LonDownS) Consortium) ; Benejam, Bessy (Barcelona Down Medical Center. Fundació Catalana Síndrome de Down) ; Beresford-Webb, J.A. (Cambridge Intellectual and Developmental Disabilities Research Group. Department of Psychiatry. University of Cambridge) ; Coppus, Antonia (Department of Primary and Community Care. Radboud University Medical Center) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Handen, Benjamin L (Department of Psychiatry. University of Pittsburgh) ; Hartley, S. (Department of Human Development & Family Studies. University of Wisconsin-Madison) ; Head, E. (Department of Pathology & Laboratory Medicine. University of California) ; Jaeger, J. (Deptment of Psychiatry and Behavioral Sciences. Albert Einstein College of Medicine) ; Levin, J. (Munich Cluster for Systems Neurology (SyNergy)) ; Loosli, S.V. (Department of Neurology. Ludwig-Maximilians-UniversitätMünchen) ; Rebillat, A.S. (Jerome Lejeune Institute) ; Sacco, S. (Jerome Lejeune Institute) ; Schmitt, F.A. (Departments of Neurology. Neurosurgery. Behavioral Science. Psychology. Psychiatry. University of Kentucky) ; Thurlow, K.E. (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ; Zaman, S. (Cambridgeshire & Peterborough NHS Foundation Trust) ; Hassenstab, J. (Washington University in St. Louis. Department of Neurology) ; Strydom, A. (South London and the Maudsley NHS Foundation Trust)
Introduction: Down syndrome (DS), a genetic variant of early onset Alzheimer's disease (AD), lacks a suitable outcome measure for prevention trials targeting predementia stages. Methods: We used cognitive test data collected in several longitudinal aging studies internationally from 312 participants with DS without dementia to identify composites that were sensitive to change over time. [...]
2021 - 10.1002/dad2.12184
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 13 Núm. 1 (2021) , p. e12184  
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