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6 p, 785.8 KB Prophylaxis with intrathecal or high-dose methotrexate in diffuse large B-cell lymphoma and high risk of CNS relapse / Bobillo, Sabela (Universitat Autònoma de Barcelona. Departament de Medicina) ; Joffe, Erel (Memorial Sloan Kettering Cancer Center (Estats Units d'Amèrica)) ; Sermer, David (Memorial Sloan Kettering Cancer Center (Estats Units d'Amèrica)) ; Mondello, Patrizia (Memorial Sloan Kettering Cancer Center (Estats Units d'Amèrica)) ; Ghione, Paola (Memorial Sloan Kettering Cancer Center (Estats Units d'Amèrica)) ; Caron, Philip C. (Memorial Sloan Kettering Cancer Center (Estats Units d'Amèrica)) ; Hamilton, Audrey (Memorial Sloan Kettering Cancer Center (Estats Units d'Amèrica)) ; Hamlin, Paul A. (Weill Cornell Medical College. Weill Cornell Department of Medicine) ; Horwitz, Steven M. (Weill Cornell Medical College. Weill Cornell Department of Medicine) ; Kumar, Anita (Weill Cornell Medical College. Weill Cornell Department of Medicine) ; Matasar, Matthew J. (Weill Cornell Medical College. Weill Cornell Department of Medicine) ; Batlevi, Connie L. (Weill Cornell Medical College. Weill Cornell Department of Medicine) ; Moskowitz, Alison (Weill Cornell Medical College. Weill Cornell Department of Medicine) ; Noy, Ariela (Weill Cornell Medical College. Weill Cornell Department of Medicine) ; Owens, Collette N. (Memorial Sloan Kettering Cancer Center (Estats Units d'Amèrica)) ; Palomba, M. Lia (Weill Cornell Medical College. Weill Cornell Department of Medicine) ; Straus, David (Weill Cornell Medical College. Weill Cornell Department of Medicine) ; von Keudell, Gottfried (Weill Cornell Medical College. Weill Cornell Department of Medicine) ; Dogan, Ahmet (Memorial Sloan Kettering Cancer Center. Department of Pathology) ; Zelenetz, Andrew D. (Weill Cornell Medical College. Weill Cornell Department of Medicine) ; Seshan, Venkatraman E. (Memorial Sloan Kettering Cancer Center) ; Younes, Anas (Weill Cornell Medical College. Weill Cornell Department of Medicine)
Although methotrexate (MTX) is the most widely used therapy for central nervous system (CNS) prophylaxis in patients with diffuse large B-cell lymphoma (DLBCL), the optimal regimen remains unclear. We examined the efficacy of different prophylactic regimens in 585 patients with newly diagnosed DLBCL and high-risk for CNS relapse, treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) or R-CHOP-like regimens from 2001 to 2017, of whom 295 (50%) received prophylaxis. [...]
2021 - 10.1038/s41408-021-00506-3
Blood Cancer Journal, Vol. 11 (june 2021)  
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