Home > Search Results: Bosdriesz, Evert
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9 p, 1.8 MB Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours / Fernandes Neto, João M. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Nadal, Ernest (Institut d'Investigació Biomèdica de Bellvitge) ; Bosdriesz, Evert (Vrije Universiteit) ; Ooft, Salo N. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Farre, Lourdes (Fundação Oswaldo Cruz (Brasil)) ; McLean, Chelsea (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Klarenbeek, Sjoerd (The Netherlands Cancer Institute. Experimental Animal Pathology) ; Jurgens, Anouk (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Hagen, Hannes (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Wang, Liqin (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Felip, Enriqueta (Universitat Autònoma de Barcelona) ; Martinez-Marti, Alex (Universitat Autònoma de Barcelona) ; Vidal, August (Institut d'Investigació Biomèdica de Bellvitge) ; Voest, Emile (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Wessels, Lodewyk F. A. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; van Tellingen, Olaf (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Villanueva, Alberto (Hospital Universitari de Bellvitge) ; Bernards, Rene (The Netherlands Cancer Institute (Amsterdam, Països Baixos))
Resistance to targeted cancer drugs is thought to result from selective pressure exerted by a high drug dose. Partial inhibition of multiple components in the same oncogenic signalling pathway may add up to complete pathway inhibition, while decreasing the selective pressure on each component to acquire a resistance mutation. [...]
2020 - 10.1038/s41467-020-16952-9
Nature communications, Vol. 11 (june 2020)  
Detailed record - Creative Commons

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