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11 p, 1.9 MB A complex interplay between H2A.Z and HP1 isoforms regulates pericentric heterochromatin / González Miranda, Jessica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Bosch-Presegué, Laia (Institut de Recerca I Innovació en Ciències de La Vida i de La Salut a La Catalunya Central) ; Marazuela Duque, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Guitart-Solanes, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Espinosa-Alcantud, María Dolores (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Fernandez, Agustín F. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Brown, Jeremy P. (Department of Immunology and Inflammation. The Hammersmith Hospital) ; Ausió, Juan (University of Victoria. Department of Biochemistry and Microbiology) ; Vazquez Prat, Berta Nieves (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Singh, Prim B. (Nazarbayev University School of Medicine) ; Fraga, Mario F. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome integrity and alterations in PCH have been linked to cancer and aging. HP1 α, β, and γ, are hallmarks of constitutive heterochromatin that are thought to promote PCH structure through binding to heterochromatin-specific histone modifications and interaction with a wide range of factors. [...]
2023 - 10.3389/fcell.2023.1293122
Frontiers in Cell and Developmental Biology, Vol. 11 (2023) , p. 1293122  
Detailed record - Creative Commons

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