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9 p, 1.3 MB The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function / Bennett, J.A. (University of Rochester Medical Center) ; Mastrangelo, M.A. (University of Rochester Medical Center) ; Ture, S.K. (University of Rochester Medical Center) ; Smith, C.O. (University of Rochester Medical Center) ; Loelius, S.G. (University of Rochester Medical Center) ; Berg, R.A. (University of Rochester Medical Center) ; Shi, X. (Beth Israel Deaconess Medical Center) ; Burke, R.M. (University of Rochester Medical Center) ; Spinelli, S.L. (University of Rochester Medical Center) ; Cameron, S.J. (University of Rochester Medical Center) ; Carey, T.E. (University of Michigan) ; Brookes, Paul S (University of Rochester Medical Center) ; Gerszten, R.E. (Beth Israel Deaconess Medical Center) ; Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ; de Vries, P.S. (The University of Texas Health Science Center at Houston) ; Huffman, Jennifer E (VA Boston Healthcare System) ; Smith, N.L. (Seattle Epidemiologic Research and Information Center) ; Morrell, C.N. (University of Rochester Medical Center) ; Lowenstein, C.J. (University of Rochester Medical Center) ; Universitat Autònoma de Barcelona
Genetic factors contribute to the risk of thrombotic diseases. Recent genome wide association studies have identified genetic loci including SLC44A2 which may regulate thrombosis. Here we show that Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial energetics. [...]
2020 - 10.1038/s41467-020-17254-w
Nature communications, Vol. 11 Núm. 1 (january 2020) , p. 3479  
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1 Cameron, Scott
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