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14 p, 9.2 MB Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1 -Mutant Myelodysplastic Syndromes With Ringed Sideroblasts / Ademà, Vera (The University of Texas MD Anderson Cancer Center) ; Ma, Feiyang (University of Michigan) ; Kanagal-Shamanna, Rashmi (The University of Texas MD Anderson Cancer Center) ; Thongon, Natthakan (The University of Texas MD Anderson Cancer Center) ; Montalban-Bravo, Guillermo (The University of Texas) ; Yang, Hui (The University of Texas) ; Peslak, Scott A. (Children's Hospital of Philadelphia (Pennsilvània)) ; Wang, Feng (The University of Texas MD Anderson Cancer Center) ; Acha, Pamela (Universitat Autònoma de Barcelona) ; Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Lockyer, Pamela (The University of Texas MD Anderson Cancer Center) ; Cassari, Margherita (University of Florence) ; Maciejewski, Jaroslaw P. (Cleveland Clinic Foundation) ; Visconte, Valeria (Cleveland Clinic Foundation) ; Gañán-Gómez, Irene (The University of Texas MD Anderson Cancer Center) ; Song, Yuanbin (Sun Yat-sen University Cancer Center) ; Bueso-Ramos, Carlos (The University of Texas MD Anderson Cancer Center) ; Pellegrini, Matteo (University of California) ; Tan, Tuyet M. (Univerity of California San Diego) ; Bejar, Rafael (Univerity of California San Diego) ; Carew, Jennifer S. (University of Arizona Cancer Center) ; Halene, Stephanie (Yale University School of Medicine) ; Santini, Valeria (University of Florence) ; Al-Atrash, Gheath (The University of Texas MD Anderson Cancer Center) ; Clise-Dwyer, Karen (The University of Texas MD Anderson Cancer Center) ; Garcia-Manero, Guillermo (The University of Texas MD Anderson Cancer Center) ; Blobel, Gerd A. (Children's Hospital of Philadelphia (Pennsilvània)) ; Colla, Simona (The University of Texas MD Anderson Cancer Center)
SF3B1 -mutant MDS-RS is associated with buildup of erythroid progenitor cells upregulating EIF2AK1-associated heme deficiency response and autophagy genes. Targeting EIF2AK1 relieves the dysregulated progenitor phenotype. [...]
2022 - 10.1158/2643-3230.BCD-21-0220
Blood Cancer Discovery, Vol. 3 (august 2022) , p. 554-567  
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