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Articles, 2 records found
Articles 2 records found  
1.
15 p, 1.7 MB Genetic and epigenetic defects of the RNA modification machinery in cancer / Orsolic, Ines (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Carrier, Arnaud (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Cancer was initially considered to be an exclusively genetic disease, but an interplay of dysregulated genetic and epigenetic mechanisms is now known to contribute to the cancer phenotype. More recently, chemical modifications of RNA molecules - the so-called epitranscriptome - have been found to regulate various aspects of RNA function and homeostasis. [...]
2023 - 10.1016/j.tig.2022.10.004
Trends in Genetics, Vol. 39 Núm. 1 (january 2023) , p. 74-88  
Detailed record - Creative Commons
2.
19 p, 964.7 KB DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness / Carrier, Arnaud (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Desjobert, Cécile (Unité de Service et de Recherche) ; Ponger, Loic (Sorbone University) ; Lamant, Laurence (Université Toulouse III Paul Sabatier) ; Bustos, Matias (Saint John's Cancer Institute) ; Torres Ferreira, Jorge (Portuguese Oncology Institute of Porto) ; Henrique, Rui (University of Porto) ; Jeronimo, Carmen (University of Porto) ; Lanfrancone, Luisa (Instituto Europeo di Oncologia) ; Delmas, Audrey (Université Toulouse III Paul Sabatier) ; Favre, Gilles (Université Toulouse III Paul Sabatier) ; Daunay, Antoine (Fondation Jean Dausset-CEPH) ; Busato, Florence (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Hoon, Dave S. B. (Saint John's Cancer Institute) ; Tost, Jorg (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Etievant, Chantal (Unité de Service et de Recherche) ; Riond, Joëlle (Université Toulouse III Paul Sabatier) ; Arimondo, Paola Barbara (Institut Pasteur)
Aberrant DNA methylation is a well-known feature of tumours and has been associated with metastatic melanoma. However, since melanoma cells are highly heterogeneous, it has been challenging to use affected genes to predict tumour aggressiveness, metastatic evolution, and patients' outcomes. [...]
2022 - 10.7554/eLife.78587
eLife, Vol. 11 (september 2022) , p. e78587  
Detailed record - Creative Commons

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