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10 p, 4.0 MB Synthesis of γ-Hydroxy-α-amino Acid Derivatives by Enzymatic Tandem Aldol Addition-Transamination Reactions / Moreno, Carlos J. (Institut de Química Avançada de Catalunya) ; Hernández, Karel (Institut de Química Avançada de Catalunya) ; Charnok, Simon J. (Prozomix Limited West End Industrial Estate) ; Gittings, Samantha (Prozomix Limited West End Industrial Estate) ; Bolte, Michael (Goethe-Universität) ; Joglar, Jesús (Institut de Química Avançada de Catalunya) ; Bujons, Jordi (Institut de Química Avançada de Catalunya) ; Parella Coll, Teodor (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear) ; Clapés, Pere (Institut de Química Avançada de Catalunya)
Three enzymatic routes toward γ-hydroxy-α-amino acids by tandem aldol addition-transamination one-pot two-step reactions are reported. The approaches feature an enantioselective aldol addition of pyruvate to various nonaromatic aldehydes catalyzed by trans - o -hydroxybenzylidene pyruvate hydratase-aldolase (HBPA) from Pseudomonas putida. [...]
2021 - 10.1021/acscatal.1c00210
ACS catalysis, Vol. 11, Issue 8 (April 2021) , p. 4660-4669  

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