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A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of the Monoclonal Antibody MHAA4549A in Patients With Acute Uncomplicated Influenza A Infection / Lim, Jeremy J. (Early Clinical Development, Genentech, Inc) ; Dar, Sadia (Clinical Research Solutions, LLC) ; Venter, Dirk (Henderson Medical Centre) ; Horcajada, Juan Pablo (Institut Hospital del Mar d'Investigacions Mèdiques) ; Kulkarni, Priya (Early Clinical Development, Genentech, Inc) ; Nguyen, Allen (Early Clinical Development, Genentech, Inc) ; McBride, Jacqueline M. (Early Clinical Development, Genentech, Inc) ; Deng, Rong (Early Clinical Development, Genentech, Inc) ; Galanter, Joshua (Early Clinical Development, Genentech, Inc) ; Chu, Tom (Early Clinical Development, Genentech, Inc) ; Newton, Elizabeth M. (Early Clinical Development, Genentech, Inc) ; Tavel, Jorge A. (Early Clinical Development, Genentech, Inc) ; Peck, Melicent C. (Early Clinical Development, Genentech, Inc) ; Universitat Autònoma de Barcelona
MHAA4549A, a human monoclonal antibody targeting the influenza A hemagglutinin stalk, neutralizes influenza A virus in animal and human volunteer challenge studies. We investigated the safety and tolerability, efficacy, and pharmacokinetics of MHAA4549A in outpatients with acute, uncomplicated influenza A infection. [...]
2021 - DOI (Digital Object Identifier)

10.1093/ofid/ofab630
Open Forum Infectious Diseases, Vol. 9 (december 2021)

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