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17 p, 7.9 MB Defect-free graphene enhances enzyme delivery to fibroblasts derived from patients with lysosomal storage disorders / Chen, Yingxian (University of Manchester. Nanomedicine Lab) ; Taufiq, Tooba (The University of Manchester) ; Zeng, Niting (University of Manchester. Department of Chemistry) ; Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ; Karakasidi, Angeliki (University of Manchester. Nanomedicine Lab) ; Church, Heather (Manchester Centre for Genomic Medicine) ; Jovanovic, Ana (Salford Royal NHS Foundation Trust) ; Jones, Simon A. (Manchester Centre for Genomic Medicine) ; Panigrahi, Adyasha (University of Manchester. Department of Chemistry) ; Larrosa, Igor (University of Manchester. Department of Chemistry) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ; Casiraghi, Cinzia (University of Manchester. Department of Chemistry) ; Vranic, Sandra (University of Manchester. Nanomedicine Lab)
Enzyme replacement therapy shows remarkable clinical improvement in treating lysosomal storage disorders. However, this therapeutic approach is hampered by limitations in the delivery of the enzyme to cells and tissues. [...]
2023 - 10.1039/d2nr04971f
Nanoscale, Vol. 15, Issue 21 (June 2023) , p. 9348-9364  

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