Home > Search Results: Comoglio, Paolo M.
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21 p, 9.8 MB Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors / Mira, Alessia (Candiolo Cancer Institute) ; Morello, Virginia (University of Torino Medical School) ; Céspedes, María Virtudes (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Perera, Timothy (OCTIMET Oncology Ltd) ; Comoglio, Paolo M. (Candiolo Cancer Institute) ; Mangues, Ramon 1957- (Institut d'Investigació Biomèdica Sant Pau) ; Michieli, Paolo (University of Torino Medical School) ; Universitat Autònoma de Barcelona
The role of paracrine Hepatocyte Growth Factor (HGF) in the resistance to angiogenesis inhibitors (AIs) is hidden in xenograft models because mouse HGF fails to fully activate human MET. To uncover it, we compared the efficacy of AIs in wild-type and human HGF knock-in SCID mice bearing orthotopic human colorectal tumors. [...]
2017 - 10.18632/oncotarget.16942
Oncotarget, Vol. 8 Núm. 24 (2017) , p. 38193-38213  
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