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21 p, 1.2 MB PAR2 Pepducin-Based Suppression of Inflammation and Itch in Atopic Dermatitis Models / Barr, T.P. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research) ; Garzia, C. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research) ; Guha, S. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research) ; Fletcher, E.K. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research) ; Nguyen, N. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research) ; Wieschhaus, A.J. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research) ; Ferrer i Caubet, Lluís (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Covic, L. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research) ; Kuliopulos, A. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research)
PAR2 has been proposed to contribute to lesion formation and intense itch in atopic dermatitis. Here, we tested the ability of a cell-penetrating pepducin, PZ-235, to mitigate the potentially deleterious effects of PAR2 in models of atopic dermatitis. [...]
2019 - 10.1016/j.jid.2018.08.019
The Journal of investigative dermatology, Vol. 139 Núm. 2 (february 2019) , p. 412-421  
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