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16 p, 1.8 MB A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction / Domingo-Rodriguez, Laura (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Ruiz de Azua, Inigo (Johannes Gutenberg University (Mainz, Alemanya). University Medical Center) ; Dominguez, Eduardo (Centre de Regulació Genòmica) ; Senabre, Eric (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Serra, Irene (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Kummer, Sami (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Navandar, Mohit (Johannes Gutenberg University. Faculty of Biology and Center of Computational Sciences) ; Baddenhausen, Sarah (University Medical Center of the Johannes Gutenberg University Mainz. Institute of Physiological Chemistry) ; Hofmann, Clementine (Johannes Gutenberg University Mainz. Focus Program Translational Neuroscience) ; Andero Galí, Raül (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ; Gerber, Susanne (Johannes Gutenberg University. Faculty of Biology and Center of Computational Sciences) ; Navarrete, Marta (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Dierssen, Mara (Institut Hospital del Mar d'Investigacions Mèdiques) ; Lutz, Beat (Leibniz Institute for Resilience Research, Mainz, Germany) ; Martín-García, Elena 1975- (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ; Maldonado, Rafael 1961- (Institut Hospital del Mar d'Investigacions Mèdiques)
Food addiction is linked to obesity and eating disorders and is characterized by a loss of behavioral control and compulsive food intake. Here, using a food addiction mouse model, we report that the lack of cannabinoid type-1 receptor in dorsal telencephalic glutamatergic neurons prevents the development of food addiction-like behavior, which is associated with enhanced synaptic excitatory transmission in the medial prefrontal cortex (mPFC) and in the nucleus accumbens (NAc). [...]
2020 - 10.1038/s41467-020-14458-y
Nature communications, Vol. 11 (february 2020)  
Detailed record - Creative Commons

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