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Resultats globals: 2 registres trobats en 0.02 segons.
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Articles 2 registres trobats  
1.
11 p, 1.2 MB Clinical outcome and biomarker assessments of a multi-centre phase II trial assessing niraparib with or without dostarlimab in recurrent endometrial carcinoma / Madariaga, Ainhoa (Universitat Autònoma de Barcelona) ; Garg, Swati (University Health Network, Toronto, Canada) ; Tchrakian, Nairi (University Health Network, Toronto, Canada) ; Dhani, Neesha C. (University of Toronto, Canada) ; Jimenez, Waldo (Juravinski Cancer Centre, Hamilton, Canada) ; Welch, Stephen (London Health Sciences Center, London, Canada) ; MacKay, Helen (Odette Cancer Centre. Sunnybrook Health Sciences Centre, Toronto, Canada) ; Ethier, Josee-Lyne (Kingston Health Sciences Cancer Centre, Kingston, Canada) ; Gilbert, Lucy (Royal Victoria Hospital, Montréal, Canada) ; Li, Xuan (University Health Network, Toronto, Canada) ; Rodriguez, Angela (University Health Network, Toronto, Canada) ; Chan, Lucy (University Health Network, Toronto, Canada) ; Bowering, Valerie (University Health Network, Toronto, Canada) ; Clarke, Blaise (University Health Network, Toronto, Canada) ; Zhang, Tong (University of Toronto, Canada) ; King, Ian (University of Toronto, Canada) ; Downs, Gregory (University of Toronto, Canada) ; Stockley, Tracy (University of Toronto, Canada) ; Wang, Lisa (University of Toronto, Toronto, Canada) ; Udagani, Smitha (University Health Network, Toronto, Canada) ; Oza, Amit M. (University of Toronto, Canada) ; Lheureux, Stephanie (University of Toronto, Canada)
This multi-centre, non-randomized, open-label, phase II trial (NCT03016338), assessed niraparib monotherapy (cohort 1, C1), or niraparib and dostarlimab (cohort 2, C2) in patients with recurrent serous or endometrioid endometrial carcinoma. [...]
2023 - 10.1038/s41467-023-37084-w
Nature communications, Vol. 14 (2023) , art. 1452  
Registre complet - Creative Commons
2.
14 p, 14.9 MB Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer / Marastoni, Stefano (University Health Network (Canadà)) ; Madariaga, Ainhoa (Universitat Autònoma de Barcelona) ; Pesic, Aleksandra (University Health Network (Canada)) ; Nair, Sree Narayanan (University Health Network (Canada)) ; Li, Zhu Juan (University Health Network (Canada)) ; Shalev, Zvi (University Health Network (Canada)) ; Ketela, Troy (University Health Network (Canada)) ; Colombo, Ilaria (University Health Network (Canada)) ; Mandilaras, Victoria (University Health Network (Canada)) ; Cabanero, Michael (University Health Network (Canada)) ; Bruce, Jeff P. (University Health Network (Canada)) ; Li, Xuan (University Health Network (Canada)) ; Garg, Swati (University Health Network (Canada)) ; Wang, Lisa (University Health Network (Canada)) ; Chen, Eric X. (University Health Network (Canada)) ; Gill, Sarbjot (University Health Network (Canada)) ; Dhani, Neesha C. (University Health Network (Canada)) ; Zhang, Wenjiang (University Health Network (Canada)) ; Pintilie, Melania (University Health Network (Canada)) ; Bowering, Valerie (University Health Network (Canada)) ; Koritzinsky, Marianne (University Health Network (Canada)) ; Rottapel, Robert (University Health Network (Canada)) ; Wouters, Bradly G. (Department of Radiation Oncology, University of Toronto) ; Oza, Amit M. (University Health Network (Canada)) ; Joshua, Anthony M. (Garvan Institute of Medical Research (Austràlia)) ; Lheureux, Stephanie (Princess Margaret Cancer Centre)
The combination of the antifungal drug itraconazole with antimalarial drug hydroxychloroquine leads to a cytotoxic lysosomal dysfunction, supporting the rational for further research on lysosomal targeting in ovarian cancer.
2022 - 10.1158/2767-9764.CRC-22-0037
Cancer Research Communications, Vol. 2 (may 2022) , p. 293-306  
Registre complet - Creative Commons

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