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18 p, 15.6 MB Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease / Garrido-Trigo, Alba (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Corraliza, Ana Maria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Veny, Marisol (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Dotti, Isabella (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Melón-Ardanaz, Elisa (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Rill, Aina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Crowell, Helena L. (Department of Molecular Life Sciences. University of Zurich. Switzerland. SIB Swiss Institute of Bioinformatics) ; Corbí, Ángel (Centro de Investigaciones Biológicas. Consejo Superior de Investigaciones Científicas (CSIC)) ; Gudiño, Victoria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Esteller, Miriam (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Álvarez-Teubel, Iris (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Aguilar, Daniel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Masamunt, M.Carmen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Killingbeck, E. (NanoString Technologies) ; Kim, Youngmi (NanoString Technologies) ; Leon, Michael (NanoString Technologies) ; Visvanathan, Sudha (Translational Medicine and Clinical Pharmacology. Boehringer-Ingelheim Pharmaceuticals Inc) ; Marchese, Domenica (Centre de Regulació Genòmica) ; Caratù, Ginevra (Centre de Regulació Genòmica) ; Martin Cardona, Albert (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Esteve, Maria (Department of Gastroenterology. Hospital Universitari Mútua Terrassa. Universitat de Barcelona) ; Panés, Julian (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Ricart, Elena (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Mereu, Elisabetta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Heyn, Holger (Universitat Pompeu Fabra) ; Salas, Azucena (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Ulcerative colitis and Crohn's disease are chronic inflammatory intestinal diseases with perplexing heterogeneity in disease manifestation and response to treatment. While the molecular basis for this heterogeneity remains uncharacterized, single-cell technologies allow us to explore the transcriptional states within tissues at an unprecedented resolution which could further understanding of these complex diseases. [...]
2023 - 10.1038/s41467-023-40156-6
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 4506  
Detailed record - Creative Commons

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