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11 p, 2.9 MB |
Serum metabolomic profiling predicts synovial gene expression in rheumatoid arthritis
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Narasimhan, Rekha (University of California) ;
Coras, Roxana (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rosenthal, Sara B. (University of California) ;
Sweeney, Shannon R. (University of Texas at Austin. Department of Nutritional Sciences & Dell Pediatric Research Institute) ;
Lodi, Alessia (University of Texas at Austin. Department of Nutritional Sciences & Dell Pediatric Research Institute) ;
Tiziani, Stefano (University of Texas at Austin. Department of Nutritional Sciences & Dell Pediatric Research Institute) ;
Boyle, David (University of California. Division of Rheumatology) ;
Kavanaugh, Arthur (University of California) ;
Guma, Monica 1971- (Universitat Autònoma de Barcelona. Departament de Medicina)
Metabolomics is an emerging field of biomedical research that may offer a better understanding of the mechanisms of underlying conditions including inflammatory arthritis. Perturbations caused by inflamed synovial tissue can lead to correlated changes in concentrations of certain metabolites in the synovium and thereby function as potential biomarkers in blood. [...]
2018 -  10.1186/s13075-018-1655-3
Arthritis research & therapy, Vol. 20 (august 2018)
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6 p, 235.8 KB |
Association of myostatin, a cytokine released by muscle, with inflammation in rheumatoid arthritis
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Murillo-Saich, Jessica D. (UC San Diego School of Medicine) ;
Vazquez-Villegas, Maria Luisa (Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara) ;
Ramirez-Villafaña, Melissa (Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara) ;
Saldaña-Cruz, Ana Miriam (Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara) ;
Aceves-Aceves, Javier A. (Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara) ;
Gonzalez-Lopez, Laura (Hospital General Regional 110 (Mèxic)) ;
Guma, Monica 1971- (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Gamez-Nava, Jorge I. (Unidad de Investigacion Biomedica 02 IMSS (Mèxic))
Supplemental Digital Content is available in the text Myostatin is a cytokine produced and released by myocytes that might have an outstanding role not only in muscle wasting during cachexia but also in inflammation. [...]
2021 - 10.1097/MD.0000000000024186
Medicine, Vol. 100 (january 2021)
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13 p, 2.0 MB |
Differences in oxylipin profile in psoriasis versus psoriatic arthritis
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Coras, Roxana (Universitat Autònoma de Barcelona) ;
Kavanaugh, Arthur (University of California San Diego. Department of Medicine) ;
Kluzniak, Angela (University of Rochester. Department of Medicine) ;
Holt, Dustina (University of Rochester. Department of Medicine) ;
Weilgosz, Amy (University of Rochester. Department of Medicine) ;
Aaron, Armando (University of California San Diego. Department of Pharmacology) ;
Quehenberger, Oswald (University of California San Diego. Department of Pharmacology) ;
Ritchlin, Christopher (University of Rochester. Department of Medicine) ;
Guma, Monica 1971- (Universitat Autònoma de Barcelona)
Oxylipins are biological lipids that have been implicated in inflammation. We previously found that certain oxylipins correlated with clinical manifestations in psoriatic arthritis (PsA) patients. Here, we compare oxylipin profiles in PsA patients and those with psoriasis (PsO) without inflammatory arthritis to identify oxylipins that associate with specific disease manifestations to better understand disease pathogenesis and identify new biomarkers. [...]
2021 - 10.1186/s13075-021-02575-y
Arthritis research & therapy, Vol. 23 (july 2021)
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18 p, 7.7 MB |
RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation
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Wong, Jerry (Department Pathology, San Diego, California) ;
Garcia-Carbonell, Ricard (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Zelic, Matija (University of Massachusetts Medical School) ;
Ho, Samuel B. (VA San Diego Healthcare System, San Diego, California) ;
Boland, Brigid S. (San Diego Digestive Disease Research Center, San Diego, California) ;
Yao, Shih-Jing (Department Pathology, San Diego, California) ;
Desai, Shalin A. (Department Pathology, San Diego, California) ;
Das, Soumita (Department Pathology, San Diego, California) ;
Planell, Núria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Harris, Philip A. (Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania) ;
Font-Burgada, Joan (Department Pathology, San Diego, California) ;
Taniguchi, Koji (Department Pathology, San Diego, California) ;
Bertin, John (University of Massachusetts Medical School) ;
Salas, Azucena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pasparakis, Manolis (University of Cologne, Cologne, Germany) ;
Gough, Pete J. (Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania) ;
Kelliher, Michelle (University of Massachusetts Medical School) ;
Karin, Michael (Department Pathology, San Diego, California) ;
Guma, Monica 1971- (Universitat Autònoma de Barcelona. Departament de Medicina)
Tumor necrosis factor (TNF) is a major pathogenic effector and a therapeutic target in inflammatory bowel disease (IBD), yet the basis for TNF-induced intestinal epithelial cell (IEC) death is unknown, because TNF does not kill normal IECs. [...]
2019 - 10.1016/j.jcmgh.2019.10.002
Cellular and Molecular Gastroenterology and Hepatology, Vol. 9 (october 2019) , p. 295-312
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7 p, 567.5 KB |
Design of an anti-inflammatory diet (ITIS diet) for patients with rheumatoid arthritis
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Bustamante, Marta F. (Department of Medicine, University of California San Diego, San Diego, CA, USA) ;
Agustín Perez, Meritxall (Department of Medicine, University of California San Diego, San Diego, CA, USA) ;
Cedola, Francesca (Department of Medicine, University of California San Diego, San Diego, CA, USA) ;
Coras, Roxana (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Narasimhan, Rekha (Department of Medicine, University of California San Diego, San Diego, CA, USA) ;
Golshan, Shahrokh (Department of Psychiatry, University of California San Diego, San Diego, CA, USA) ;
Guma, Monica 1971- (Universitat Autònoma de Barcelona. Departament de Medicina)
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability. Although recent pharmaceutical advances have improved treatment of RA, patients with RA often inquire about dietary interventions to improve RA symptoms, as they perceive rapid changes in their symptoms after consumption of certain foods. [...]
2020 - 10.1016/j.conctc.2020.100524
Contemporary Clinical Trials Communications, Vol. 17 (january 2020)
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