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Progression of Interstitial Fibrosis and Tubular Atrophy in Low Immunological Risk Renal Transplants Monitored by Sequential Surveillance Biopsies : The Influence of TAC Exposure and Metabolism / Chamoun, Betty (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Torres, Irina B. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gabaldón, Alejandra (Hospital Universitari Vall d'Hebron) ; Sellarés Nadal, Joana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Perelló, Manel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Castellà Fernández, Eva (Hospital Universitari Vall d'Hebron) ; Guri, Xavier (Hospital Universitari Vall d'Hebron) ; Salcedo, Maite (Hospital Universitari Vall d'Hebron) ; Toapanta, Néstor (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cidraque, Ignacio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Moreso, Francesc (Universitat Autònoma de Barcelona. Departament de Medicina) ; Seron, Daniel (Universitat Autònoma de Barcelona. Departament de Medicina)
The combination of tacrolimus (TAC) and mycophenolate is the most widely employed maintenance immunosuppression in renal transplants. Different surrogates of tacrolimus exposure or metabolism such as tacrolimus trough levels (TAC-C), coefficient of variation of tacrolimus (CV-TAC-C), time in therapeutic range (TTR), and tacrolimus concentration dose ratio (C/D) have been associated with graft outcomes. [...]
2021 - DOI (Digital Object Identifier)

10.3390/jcm10010141
Journal of clinical medicine, Vol. 10 (january 2021)

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