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17 p, 5.1 MB Robust temporal map of human in vitro myelopoiesis using single-cell genomics / Alsinet, Clara (Open Targets. Wellcome Genome Campus) ; Primo, Maria Nascimento (Open Targets. Wellcome Genome Campus) ; Lorenzi, Valentina (Wellcome Sanger Institute. Wellcome Genome Campus) ; Bello, Erica (Open Targets. Wellcome Genome Campus) ; Kelava, Iva (Wellcome Sanger Institute. Wellcome Genome Campus) ; Jones, Carla P. (Wellcome Sanger Institute. Wellcome Genome Campus) ; Vilarrasa Blasi, Roser (Wellcome Sanger Institute. Wellcome Genome Campus) ; Sancho Serra, Carmen (Wellcome Sanger Institute. Wellcome Genome Campus) ; Knights, Andrew J. (Wellcome Sanger Institute. Wellcome Genome Campus) ; Park, Jong Eun (Korea Advanced Institute of Science and Technology) ; Wyspianska, Beata S. (Immunology Research Unit. Medicines Research Centre. GlaxoSmithKline) ; Trynka, Gosia (Open Targets. Wellcome Genome Campus) ; Tough, David F. (Immunology Research Unit. Medicines Research Centre. GlaxoSmithKline) ; Bassett, Andrew (Open Targets. Wellcome Genome Campus) ; Gaffney, Daniel J. (Wellcome Sanger Institute. Wellcome Genome Campus) ; Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vento Tormo, Roser (Wellcome Sanger Institute. Wellcome Genome Campus)
Myeloid cells are central to homeostasis and immunity. Characterising in vitro myelopoiesis protocols is imperative for their use in research, immunotherapies, and understanding human myelopoiesis. Here, we generate a >470K cells molecular map of human induced pluripotent stem cells (iPSC) differentiation into macrophages. [...]
2022 - 10.1038/s41467-022-30557-4
Nature communications, Vol. 13 Núm. 1 (december 2022) , p. 2885  
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