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12 p, 4.8 MB Down syndrome and leukemia : from basic mechanisms to clinical advances / Baruchel, André (Hôpital Universitaire Robert Debré, Paris, France) ; Bourquin, Jean Pierre (University Children's Hospital, Zurich, Switzerland) ; Crispino, John (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ; Cuartero, Sergi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Hasle, Henrik (Aarhus University Hospital (Aarhus, Dinamarca)) ; Hitzler, Johann (The Hospital for Sick Children, Toronto, Canada) ; Klusmann, Jan Henning (Goethe University Frankfurt, Germany) ; Izraeli, Shai (Tel Aviv University, Tel Aviv, Israel) ; Lane, Andrew A. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ; Malinge, Sebastien (Cancer Centre, Perth, Western Australia) ; Rabin, Karen R. (University of Oxford, UK) ; Roberts, Irene (University of Oxford, UK) ; Ryeom, Sandra (Columbia University Irving Medical Center, New York, USA) ; Tasian, Sarah K. (University of Pennsylvania Perelman School of Medicine, Philadelphia, USA) ; Wagenblast, Elvin (Icahn School of Medicine at Mount Sinai, New York, USA)
Children with Down syndrome (DS, trisomy 21) are at a significantly higher risk of developing acute leukemia compared to the overall population. Many studies investigating the link between trisomy 21 and leukemia initiation and progression have been conducted over the last two decades. [...]
2023 - 10.3324/haematol.2023.283225
Haematologica, Vol. 108 Núm. 10 (october 2023) , p. 2570-2581  

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