Home > Search Results: O'Byrne, Sorcha
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Articles, 2 records found
Articles 2 records found  
1.
14 p, 1.0 MB CD34 + CD19 − CD22 + B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies / Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Barrera, Susana (Universidad de Salamanca) ; Bataller, Alex (Hospital Clínic i Provincial de Barcelona) ; Ortiz-Maldonado, Valentín (Hospital Clínic i Provincial de Barcelona) ; Elliot, Natalina (John Radcliffe Hospital (Oxford, Regne Unit)) ; O'Byrne, Sorcha (John Radcliffe Hospital (Oxford, Regne Unit)) ; Wang, Guanlin (University of Oxford) ; Rovira, Montse (University of Oxford) ; Gutiérrez-Agüera, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Trincado Alonso, Juan Luis, 1987- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; González-González, María (Universidad de Salamanca) ; Morgades, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sorigue, Marc (Universitat Autònoma de Barcelona) ; Bárcena, Paloma (Universidad de Salamanca) ; Zanetti, S. R (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Torrebadell, Montse (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ; Vega-Garcia, Nerea (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ; Rives, Susana (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ; Mallo, Maria del Mar (Universitat Autònoma de Barcelona) ; Sole, F (Universitat Autònoma de Barcelona) ; Mead, Adam J. (Centro Nacional de Investigaciones Oncológicas Carlos III (Espanya)) ; Roberts, Irene (Oxford Biomedical Research Centre) ; Thongjuea, Supat (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ; Psaila, Bethan (Oxford Biomedical Research Centre) ; Juan, Manel (Hospital Clínic i Provincial de Barcelona) ; Delgado, Julio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Urbano-Ispizúa, Alvaro (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Ribera, Jose-Maria (Universitat Autònoma de Barcelona) ; Orfao, Alberto (Universidad de Salamanca) ; Roy, Anindita (Oxford Biomedical Research Centre) ; Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Three article in this issue present preclinical data aimed at improving immunotherapeutic approaches for relapsed B- and T-cell acute lymphoblastic leukemia (T-ALL). Chimeric antigen receptor T (CAR-T) cell therapy directed against relapsed T-ALL is hampered by difficulty in identifying a target antigen that is not also expressed on healthy T cells, risking "fratricide" with T-cell aplasia and loss of the CAR-T cells. [...]
2022 - 10.1182/blood.2021014840
Blood, Vol. 140 (july 2022) , p. 38-44  
Detailed record - Creative Commons
2.
17 p, 2.3 MB H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells / Godfrey, L. (University of Oxford. Department of Medicine) ; Crump, N. T. (University of Oxford. Department of Medicine) ; O'Byrne, Sorcha (Department of Paediatrics. University of Oxford) ; Lau, I. J. (University of Oxford. Department of Medicine) ; Rice, S. (University of Oxford. Department of Medicine) ; Harman, J. R. (University of Oxford. Department of Medicine) ; Jackson, T. (Department of Paediatrics. University of Oxford) ; Elliott, N. (Department of Paediatrics. University of Oxford) ; Buck, G. (Department of Paediatrics. University of Oxford) ; Connor, C. (Great Ormond Street Hospital for Children (Londres)) ; Thorne, R. (University of Oxford. Department of Medicine) ; Knapp, D. J. H. F. (MRC Weatherall Institute of Molecular Medicine. Radcliffe Department of Medicine. University of Oxford) ; Heidenreich, O. (Newcastle University. Wolfson Childhood Cancer Research Centre) ; Vyas, P. (Department of Haematology. Oxford University Hospitals NHS Foundation Trust) ; Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Inglott, S. (Great Ormond Street Hospital for Children (Londres)) ; Ancliff, P. (Great Ormond Street Hospital for Children (Londres)) ; Geng, H. (Department of Laboratory Medicine. University of California. San Francisco) ; Roberts, I. (Department of Paediatrics. University of Oxford) ; Roy, A. (Department of Paediatrics. University of Oxford) ; Milne, T. A. (University of Oxford. Department of Medicine) ; Universitat Autònoma de Barcelona
MLL gene rearrangements (MLLr) are a common cause of aggressive, incurable acute lymphoblastic leukemias (ALL) in infants and children, most of which originate in utero. The most common MLLr produces an MLL-AF4 fusion protein. [...]
2021 - 10.1038/s41375-020-0808-y
Leukemia, Vol. 35 Núm. 1 (january 2021) , p. 90-106  
Detailed record - Creative Commons

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1 O'Byrne, S.
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