Pagenstecher, Axel - Search Results - UAB Digital Repository of Documents

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Correlation of MR-Based Metabolomics and Molecular Profiling in the Tumor Microenvironment of Temozolomide-Treated Orthotopic GL261 Glioblastoma in Mice / Zhao, Kai (Philipps University Marburg) ; Calero-Perez, Pilar (Institut d'Investigació Biomèdica Sant Pau) ; Bopp, Miriam H.A. (Center for Mind. Brain and Behavior (CMBB)) ; Möschl, Vincent (Philipps University Marburg) ; Pagenstecher, Axel (Philipps-University Marburg) ; Mulero-Acevedo, Marta (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Vázquez, Mario (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Barcia, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Nimsky, Christopher (Center for Mind. Brain and Behavior (CMBB)) ; Rusch, Tillmann (Philipps University Marburg) ; Bartsch, Joerg Walter. (Center for Mind. Brain and Behavior (CMBB)) ; Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The tumor microenvironment in glioblastoma (GB) is considered to be "cold", i. e. , the fraction of cytotoxic T cells, for instance, is low. Instead, macrophages are the major immune cell population in GB, which stem either from tissue response (resident microglia) or recruitment of macrophages from the periphery, thereby undergoing tumor-dependent "imprinting" mechanisms by which macrophages can adapt a tumor-supportive phenotype. [...]
2023 - DOI (Digital Object Identifier)

10.3390/ijms242417628
International journal of molecular sciences, Vol. 24 Núm. 24 (december 2023) , p. 17628

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