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8 p, 835.5 KB |
Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury
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Pickkers, Peter (Nijmegen) ;
Angus, Derek C (University of Pittsburgh School of Medicine) ;
Arend, Jacques (AM-Pharma BV) ;
Bellomo, Rinaldo (Austin Hospital) ;
van den Berg, Erik (AM-Pharma BV) ;
Bernholz, Juliane (AM-Pharma BV) ;
Bestle, Morten (Copenhagen) ;
Broglio, Kristine (Berry Consultants) ;
Carlsen, Jan (AM-Pharma BV) ;
Doig, Christopher J ;
Ferrer, Ricard (Universitat Autònoma de Barcelona. Departament d'Infermeria) ;
Joannidis, Michael (Medical University Innsbruck) ;
Francois, Bruno (University of Limoges) ;
Doi, Kent (The University of Tokyo Hospital) ;
Kellum, John A ;
Laterre, Pierre-François (Brussels) ;
Liu, Kathleen (University of California San Fransisco) ;
Mehta, Ravindra L (University of California) ;
Murray, Patrick T (Dublin) ;
Ostermann, Marlies (King's College London) ;
Pettilä, Ville (Helsinki) ;
Richards, Sharon (PHASTAR) ;
Young, Paul (Wellington) ;
Zarbock, Alexander (Universität Münster) ;
Kjølbye, Anne Louise (AM-Pharma BV)
Sepsis, the leading cause of acute kidney injury (AKI), is associated with a high morbidity and mortality. Alkaline phosphatase (ALP) is an endogenous detoxifying enzyme. A recombinant human ALP compound, ilofotase alfa, showed no safety or tolerability concerns in a phase 2 trial. [...]
2023 - 10.1136/bmjopen-2022-065613
BMJ open, Vol. 13 (april 2023)
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10 p, 1.2 MB |
Influenza and associated co-infections in critically ill immunosuppressed patients
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Martin-Loeches, Ignacio (St. James's Hospital ( Dublín, Irlanda)) ;
Lemiale, Virginie (Hôpital Saint-Louis and Paris Diderot Sorbonne University. Medical Intensive Care Unit) ;
Geoghegan, Pierce (Trinity College. Department of Clinical Medicine, Wellcome Trust-HRB Clinical Research Facility, St. James Hospital) ;
McMahon, Mary Aisling (Trinity College. Department of Clinical Medicine, Wellcome Trust-HRB Clinical Research Facility, St. James Hospital) ;
Pickkers, Peter (Radboud University Medical Centre. Department of Intensive Care Medicine) ;
Soares, Marcio (D'Or Institute for Research and Education (Rio de Janeiro, Brasil)) ;
Perner, Anders (University of Copenhagen) ;
Meyhoff, Tine Sylvest (University of Copenhagen) ;
Bukan, Ramin Brandt (Herlev University Hospital. Department of Anesthesiology I) ;
Rello, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bauer, Philippe (Mayo Clinic. Pulmonary and Critical Care Medicine) ;
van de Louw, Andry (Penn State University College of Medicine. Division of Pulmonary and Critical Care) ;
Taccone, Fabio Silvio (Université Libre de Bruxelles (ULB). Department of Intensive Care, Hôpital Erasme) ;
Salluh, Jorge (D'Or Institute for Research and Education (Rio de Janeiro, Brasil)) ;
Hemelaar, Pleun (Radboud University Medical Centre. Department of Intensive Care Medicine) ;
Schellongowski, Peter (Medical University of Vienna. Department of Medicine I) ;
Rusinova, Katerina (Charles University. Faculty of Medicine in Hradec Králové) ;
Terzi, Nicolas (Université Grenoble-Alpes. CHU Grenoble Alpes, Service de Réanimation Médicale, Faculté de Médecine de Grenoble, INSERM U1042) ;
Mehta, Sangeeta (University of Toronto. Department of Medicine) ;
Antonelli, Massimo (Università Cattolica del Sacro Cuore. Agostino Gemelli University Hospital) ;
Kouatchet, Achille (University Hospital of Angers. Department of Medical Intensive Care Medicine) ;
Klepstad, Pål (Norwegian University of Science and Technology) ;
Valkonen, Miia (Helsinki University Hospital (Finlàndia)) ;
Landburg, Precious Pearl (University Medical Center Groningen. Department of Critical Care) ;
Barratt-Due, Andreas (University of Oslo. Department of Immunology-Department of Emergencies and Critical Care) ;
Bruneel, Fabrice (Centre Hospitalier de Versailles. Medical-Surgical Intensive Care Unit) ;
Pène, Frédéric (Medical ICU, Cochin Hospital, Assistance Publique-Hôpitaux de Paris and University Paris Descartes) ;
Metaxa, Victoria (King's College Hospital NHS Foundation Trust) ;
Moreau, Anne Sophie (University of Lille. Critical Care Center, CHU Lille, School of Medicine) ;
Souppart, Virginie (Hôpital Saint-Louis and Paris Diderot Sorbonne University. Medical Intensive Care Unit) ;
Burghi, Gastón (Hospital Maciel. Terapia Intensiva) ;
Girault, Christophe (Normandie Univ, UNIROUEN, EA-3830, Rouen University Hospital. Department of Medical Intensive Care) ;
Silva, Ulysses V. A. (ICU, Fundação Pio XII - Barretos Cancer Hospital) ;
Montini, Luca (Università Cattolica del Sacro Cuore. Agostino Gemelli University Hospital) ;
Barbier, Francois (La Source Hospital - CHR Orléans. Medical Intensive Care Unit) ;
Nielsen, Lene B. (Odense University Hospital (Dinamarca)) ;
Gaborit, Benjamin (CHU de Nantes) ;
Mokart, Djamel (Institut Paoli-Calmettes. Réanimation Polyvalente et Département d'Anesthésie et de Réanimation) ;
Chevret, Sylvie (ECSTRA Team, Biostatistics and Clinical Epidemiology, UMR 1153, INSERM, Paris Diderot Sorbonne University and Service de Biostatistique et Information Médicale AP-HP, Hôpital Saint-Louis) ;
Azoulay, Elie (Hôpital Saint-Louis and Paris Diderot Sorbonne University. Medical Intensive Care Unit) ;
Universitat Autònoma de Barcelona
It is unclear whether influenza infection and associated co-infection are associated with patient-important outcomes in critically ill immunocompromised patients with acute respiratory failure. Preplanned secondary analysis of EFRAIM, a prospective cohort study of 68 hospitals in 16 countries. [...]
2019 - 10.1186/s13054-019-2425-6
Critical Care, Vol. 23 (may 2019)
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