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Public Cord Blood Banks as a source of starting material for clinical grade HLA-homozygous induced pluripotent stem cells / Alvarez-Palomo, Belén (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Veiga, Anna (Institut d'Investigació Biomèdica de Bellvitge) ; Raya, Ángel (Institut d'Investigació Biomèdica de Bellvitge) ; Codinach, Margarita (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Torrents, Silvia (Banc de Sang i Teixits BST) ; Ponce Verdugo, Laura (Centro de Transfusión, Tejidos y Células de Málaga) ; Rodriguez-Aierbe, Clara (Osakidetza (Galdakao, Espanya)) ; Cuellar, Leopoldo (Axencia Galega de Sangue, Órganos e Tecidos (Santiago, Espanya)) ; Alenda, Raquel (Centro de Transfusión de la Comunidad de Madrid) ; Arbona, Cristina (Centro de Transfusión de la Comunidad Valenciana) ; Hernández-Maraver, Dolores (Organización Nacional de Trasplantes (Madrid, Espanya)) ; Fusté, Cristina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Querol, Sergi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
The increasing number of clinical trials for induced pluripotent stem cell (iPSC)-derived cell therapy products makes the production on clinical grade iPSC more and more relevant and necessary. Cord blood banks are an ideal source of young, HLA-typed and virus screened starting material to produce HLA-homozygous iPSC lines for wide immune-compatibility allogenic cell therapy approaches. [...]
2022 - DOI (Digital Object Identifier)

10.1186/s13287-022-02961-6
Stem cell research & therapy, Vol. 13 (august 2022)

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