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10 p, 860.0 KB Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19 / Solanich, Xavier (Hospital Universitari de Bellvitge) ; Vargas-Parra, Gardenia (Centro de Investigación Biomédica en Red de Cáncer) ; Van der Made, Caspar I oud (University Medical Center) ; Schuurs-Hoeijmakers, Janneke (Radboud University Medical Center) ; Antolí, Arnau (Hospital Universitari de Bellvitge) ; Del Valle, Jesús (Centro de Investigación Biomédica en Red de Cáncer) ; Rocamora-Blanch, Gemma (Hospital Universitari de Bellvitge) ; Setién, Fernando (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Van Reijmersdal, Simon V (Radboud University Medical Center) ; Riera Mestre, Antoni (Universitat de Barcelona) ; Sabater-Riera, Joan (Hospital Universitari de Bellvitge) ; Capellá, G. (Gabriel) (Centro de Investigación Biomédica en Red de Cáncer) ; Van de Veerdonk, Frank L v (Radboud University Medical Center) ; Van der Hoven, Ben (Erasmus MC) ; Corbella, Xavier (Universitat Internacional de Catalunya) ; Hoischen, Alexander (Radboud University Medical Center) ; Lázaro, Conxi (Centro de Investigación Biomédica en Red de Cáncer)
Introduction: Loss-of-function TLR7 variants have been recently reported in a small number of males to underlie strong predisposition to severe COVID-19. We aimed to determine the presence of these rare variants in young men with severe COVID-19. [...]
2021 - 10.3389/fimmu.2021.719115
Frontiers in immunology, Vol. 12 (23 2021) , p. 719115  
Detailed record - Creative Commons

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