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Multi-ancestry genome-wide association study of asthma exacerbations
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Herrera-Luis, Esther (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Ortega, Victor E. (División de Medicina Respiratoria. Departamento de Medicina Interna. Mayo Clinic) ;
Ampleford, Elizabeth J. (Department of Internal Medicine. Center for Precision Medicine. Wake Forest School of Medicine) ;
Sio, Yang Yie (Department of Biological Sciences. National University of Singapore) ;
Granell, Raquel (MRC Integrative Epidemiology Unit (IEU). Population Health Sciences. Bristol Medical School. University of Bristol) ;
de Roos, Emmely (Department of Respiratory Medicine. Ghent University Hospital) ;
Terzikhan, Natalie (Department of Respiratory Medicine. Ghent University Hospital) ;
Vergara, Ernesto Elorduy (Institute of Computation Biology. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Hernandez-Pacheco, Natalia (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Perez-Garcia, Javier (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Martin-Gonzalez, Elena (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Lorenzo-Diaz, Fabian (Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias. Universidad de La Laguna) ;
Hashimoto, Simone (Department of Respiratory Medicine. Amsterdam University Medical Center. University of Amsterdam) ;
Brinkman, Paul (Department of Respiratory Medicine. Amsterdam University Medical Center. University of Amsterdam) ;
Jorgensen, Andrea L. (Department of Health Data Science. Institute of Population Health. University of Liverpool) ;
Yan, Qi (Department of Obstetrics and Gynecology. Columbia University Irving Medical Center) ;
Forno, Erick (Division of Pediatric Pulmonary Medicine. UPMC Children's Hospital of Pittsburgh. University of Pittsburgh) ;
Vijverberg, Susanne J. (Department of Paediatric Respiratory Medicine and Allergy. Emma's Children Hospital. Amsterdam UMC. University of Amsterdam) ;
Lethem, Ryan (MRC Integrative Epidemiology Unit (IEU). Population Health Sciences. Bristol Medical School. University of Bristol) ;
Espuela-Ortiz, Antonio (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Gorenjak, Mario (Center for Human Molecular Genetics and Pharmacogenomics. Faculty of Medicine. University of Maribor) ;
Eng, Celeste (Department of Medicine. University of California San Francisco) ;
González-Pérez, Ruperto (Unidad de Asma Grave. Servicio de Alergología. Hospital Universitario de Canarias.) ;
Hernández-Pérez, José M. (Hospital General de La Palma. Servicio de Neumología) ;
Poza-Guedes, Paloma (Hospital Universitario de Canarias. Unidad de Asma Grave. Servicio de Alergología) ;
Sardón, Olaia (Universidad del País Vasco. Departamento de Pediatría) ;
Corcuera, Paula (Hospital Universitario Donostia. Division of Pediatric Respiratory Medicine) ;
Hawkins, Greg A. (Department of Biochemistry. Wake Forest School of Medicine) ;
Marsico, Annalisa (Computational Health Center. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Bahmer, Thomas (Airway Research Center North (ARCN). Members of the Germany Center for Lung Research (DZL)) ;
Rabe, Klaus F. (Airway Research Center North (ARCN). Members of the Germany Center for Lung Research (DZL)) ;
Hansen, Gesine (Department of Pediatric Pneumology. Allergology and Neonatology. Hannover Medical School) ;
Kopp, Matthias V. (Department of Paediatric Respiratory Medicine. Inselspital. University Children's Hospital of Bern. University of Bern) ;
Rios, Raimon (Programa de Pós Graduação em Imunologia (PPGIm). Instituto de Ciências da Saúde. Universidade Federal da Bahia (UFBA)) ;
Cruz, Maria Jesús (Hospital Universitari Vall d'Hebron) ;
González-Barcala, Francisco Javier (Complejo Hospitalario Universitario de Santiago de Compostela. Servicio de Neumología) ;
Olaguibel, José María (Complejo Hospitalario de Navarra) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz. Instituto de Investigación Hospital Universitario La Paz. Servicio de Alergología) ;
Canino, Glorisa (Behavioral Sciences Research Institute. University of Puerto Rico) ;
Cloutier, Michelle (Department of Pediatrics. University of Connecticut) ;
Del Pozo, Victoria (Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz. Servicio de Inmunología) ;
Rodriguez-Santana, Jose R. (Centro de Neumología Pediátrica) ;
Korta-Murua, Javier (Universidad del País Vasco. Departamento de Pediatría) ;
Villar, Jesús (Hospital Universitario de Gran Canaria Doctor Negrín. Multidisciplinary Organ Dysfunction Evaluation Research Network. Research Unit) ;
Potočnik, Uros (Laboratory for Biochemistry. Molecular Biology and Genomics. Faculty for Chemistry and Chemical Engineering. University of Maribor) ;
Figueiredo, Camila (Instituto de Ciências da Saúde. Universidade Federal da Bahia) ;
Kabesch, Michael (Department of Paediatric Pneumology and Allergy. University Children's Hospital Regensburg (KUNO)) ;
Mukhopadhyay, Somnath (Population Pharmacogenetics Group. Biomedical Research Institute. Ninewells Hospital and Medical School. University of Dundee) ;
Pirmohamed, Munir (Department of Pharmacology and Therapeutics. Institute of Systems. Molecular and Integrative Biology. University of Liverpool) ;
Hawcutt, Daniel (NIHR Alder Hey Clinical Research Facility. Alder Hey Children's Hospital) ;
Melén, Erik (Sachs' Children's Hospital. South General Hospital) ;
Palmer, Colin (Population Pharmacogenetics Group. Biomedical Research Institute. Ninewells Hospital and Medical School. University of Dundee) ;
Turner, Steve (Child Health. University of Aberdeen) ;
Maitland-van der Zee, Anke H. (Department of Paediatric Respiratory Medicine and Allergy. Emma's Children Hospital. Amsterdam UMC. University of Amsterdam) ;
von Mutius, Erika (Comprehensive Pneumology Center Munich (CPC-M). Member of the German Center for Lung Research) ;
Celedón, Juan C. (Division of Pediatric Pulmonary Medicine. UPMC Children's Hospital of Pittsburgh. University of Pittsburgh) ;
Brusselle, Guy (Department of Respiratory Medicine. Erasmus University Medical Center) ;
Chew, Fook Tim (Department of Biological Sciences. National University of Singapore) ;
Bleecker, Eugene (Division of Genetics. Genomics. and Precision Medicine. Department of Internal Medicine. University of Arizona College of Medicine) ;
Meyers, Deborah (Division of Genetics. Genomics. and Precision Medicine. Department of Internal Medicine. University of Arizona College of Medicine) ;
Burchard, Esteban G. (Department of Bioengineering and Therapeutic Sciences. University of California San Francisco) ;
Pino-Yanes, Maria (Universidad de la Laguna. Instituto de Tecnologías Biomédicas)
Background: Asthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on quality of life, and risk of mortality. The genetic basis of asthma exacerbations has been studied in several populations, but no prior study has performed a multi-ancestry meta-analysis of genome-wide association studies (meta-GWAS) for this trait. [...]
2022 -  10.1111/pai.13802
Pediatric Allergy and Immunology, Vol. 33 Núm. 6 (june 2022) , p. e13802
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