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9 p, 1.1 MB |
Impact of Diabetes on 10-Year Outcomes Following ST-Segment-Elevation Myocardial Infarction : Insights From the EXAMINATION-EXTEND Trial
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Spione, Francesco (Hospital Clínic i Provincial de Barcelona) ;
Arevalos, Victor (Hospital Clínic i Provincial de Barcelona) ;
Gabani, Rami (Hospital Clínic i Provincial de Barcelona) ;
Ortega-Paz, Luis (University of Florida College of Medicine) ;
Gomez Lara, Josep (Hospital Universitari de Bellvitge) ;
Jimenez-Diaz, Victor (Instituto De Investigación Sanitaria Galicia Sur) ;
Jimenez, Marcelo (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Jiménez-Quevedo, Pilar (Hospital Clínico Universitario San Carlos (Madrid)) ;
Diletti, Roberto (Thoraxcenter (Rotterdam, Països Baixos)) ;
Pineda Rocamora, Javier (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Campo, Gianluca (Azienda Ospedaliera Universitaria di Ferrara (Cona, Itàlia)) ;
Silvestro, Antonio (University Hospital Bolognini Seriate (Bergamo, Itàlia)) ;
Maristany, Jaume (Hospital Universitari Son Dureta (Palma de Mallorca, Balears)) ;
Flores, Xacobe (Hospital Universitario A Coruña (Galícia)) ;
Oyarzabal, Loreto (Hospital Universitari de Bellvitge) ;
Bastos Fernández, Guillermo (Instituto De Investigación Sanitaria Galicia Sur) ;
Iñiguez, Andrés (Hospital Álvaro Cunqueiro (Vigo)) ;
Serra, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Escaned, Javier (Hospital Clínico Universitario San Carlos (Madrid)) ;
Ielasi, Alfonso (University Hospital Bolognini Seriate (Bergamo, Itàlia)) ;
Tespili, Maurizio (University Hospital Bolognini Seriate (Bergamo, Itàlia)) ;
Lenzen, Mattie (Thoraxcenter (Rotterdam, Països Baixos)) ;
Gonzalo, Nieves (University Hospital San Carlos (Madrid)) ;
Bordes, Pascual (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Tebaldi, Matteo (Azienda Ospedaliera Universitaria di Ferrara (Cona, Itàlia)) ;
Biscaglia, Simone (Azienda Ospedaliera Universitaria di Ferrara (Cona, Itàlia)) ;
Al-Shaibani, Soheil (Thoraxcenter (Rotterdam, Països Baixos)) ;
Romaguera, Rafael (Hospital Universitari de Bellvitge) ;
Gomez-Hospital, Joan Antoni (Hospital Universitari de Bellvitge) ;
Rodes-Cabau, Josep (Hospital Clínic i Provincial de Barcelona) ;
Serruys, Patrick W. (National University of Ireland (Galway, Irlanda)) ;
Sabaté Tenas, Manel (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Brugaletta, Salvatore (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Long-term outcomes of ST-segment-elevation myocardial infarction in patients with diabetes have been barely investigated. The objective of this analysis from the EXAMINATION-EXTEND (10-Years Follow-Up of the EXAMINATION trial) trial was to compare 10-year outcomes of patients with ST-segment-elevation myocardial infarction with and without diabetes. [...]
2022 -  10.1161/JAHA.122.025885
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 11 Núm. 23 (2022) , p. e025885
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7 p, 467.1 KB |
Quality of care assessment and improvement in aortic stenosis - rationale and design of a multicentre registry (IMPULSE)
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Frey, Norbert (University of Kiel) ;
Steeds, Richard P. (University of Birmingham) ;
Serra, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Schulz, Eberhard (University Clinic Mainz) ;
Baldus, Stephan (Heart Center of the University Clinic Cologne) ;
Lutz, Matthias (University of Kiel) ;
Pohlmann, Christiane (Institute for Pharmacology and Preventive Medicine) ;
Kurucova, Jana (Edwards Lifesciences) ;
Bramlage, Peter (Institute for Pharmacology and Preventive Medicine) ;
Messika-Zeitoun, David (Bichat Hospital) ;
Universitat Autònoma de Barcelona
Severe aortic stenosis (AS) is a common, serious valve disease in which no effective medical therapy is available and, if not treated by intervention, has a 5-year survival of only 40-60%. Despite the availability of guidelines supporting the effective use of surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI) to treat the majority of these patients, adherence to these guidelines in clinical practice is still unsatisfactory. [...]
2017 - 10.1186/s12872-016-0439-4
BMC Cardiovascular disorders, Vol. 17 Núm. 1 (may 2017) , p. 5
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16 p, 1.5 MB |
Facilitated Data Relay and Effects on Treatment of Severe Aortic Stenosis in Europe
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Steeds, Richard P. (University of Birmingham) ;
Lutz, Matthias (University of Kiel) ;
Thambyrajah, Jeetendra (James Cook Hospital) ;
Serra Peñaranda, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Schulz, Eberhard (University Clinic Mainz) ;
Maly, Jiri (Charles University) ;
Aiello, Marco (Foundation IRCCS Policlinico S.Matteo) ;
Rudolph, Tanja K. (University of Cologne Heart Center) ;
Lloyd, Guy (St Bartholomew's Hospital) ;
Bortone, Alessandro Santo (University of Bari) ;
Hauptmann, Karl Eugen (Krankenhaus der Barmherzigen Brüder Trier) ;
Clerici, Alberto (University of Turin) ;
Delle-Karth, Georg (Hietzing Hospital) ;
Rieber, Johannes (University of Munich) ;
Indolfi, Ciro (University Magna Graecia) ;
Mancone, Massimo (Sapienza University of Rome) ;
Belle, Loic (Centre Hospital d'Annecy) ;
Lauten, Alexander (University Heart Center & Charité) ;
Arnold, Martin (University Hospital) ;
Bouma, Berto J. (University of Amsterdam) ;
Deutsch, Cornelia (Institute for Pharmacology and Preventive Medicine) ;
Kurucova, Jana (Edwards Lifesciences) ;
Thoenes, Martin (Edwards Lifesciences) ;
Bramlage, Peter (Institute for Pharmacology and Preventive Medicine) ;
Frey, Norbert (University of Kiel) ;
Messika-Zeitoun, David (University of Ottawa Heart Institute) ;
Universitat Autònoma de Barcelona
Many patients with severe aortic stenosis are referred late with advanced symptoms or inappropriately denied intervention. The objective was to investigate whether a structured communication to referring physicians (facilitated data relay) might improve the rate and timeliness of intervention. [...]
2019 - 10.1161/JAHA.119.013160
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 8 Núm. 19 (january 2019) , p. e013160
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11 p, 1.3 MB |
Assessment of Platelet REACtivity After Transcatheter Aortic Valve Replacement : The REAC-TAVI Trial
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Jimenez Diaz, Victor Alfonso (Hospital Álvaro Cunqueiro (Vigo)) ;
Tello-Montoliu, Antonio (Centro de Investigación en Red de Enfermedades Cardiovasculares) ;
Moreno, Raul (Hospital Universitario La Paz (Madrid)) ;
Cruz Gonzalez, Ignacio (Hospital Universitario de Salamanca) ;
Baz Alonso, Jose Antonio (Hospital Álvaro Cunqueiro (Vigo)) ;
Romaguera, Rafael (Hospital Universitari de Bellvitge) ;
Molina Navarro, Eduardo (Hospital Universitario Virgen de las Nieves (Granada)) ;
Juan Salvadores, Pablo (Fundación Biomédica Galicia Sur) ;
Paredes Galan, Emilio (Hospital Álvaro Cunqueiro (Vigo)) ;
De Miguel-Castro, Antonio (Hospital Álvaro Cunqueiro (Vigo)) ;
Bastos Fernandez, Guillermo (Hospital Álvaro Cunqueiro (Vigo)) ;
Ortiz Saez, Alberto (Hospital Álvaro Cunqueiro (Vigo)) ;
Fernandez Barbeira, Saleta (Hospital Álvaro Cunqueiro (Vigo)) ;
Raposeiras Roubin, Sergio (Hospital Álvaro Cunqueiro (Vigo)) ;
Ocampo Miguez, Juan (Hospital Álvaro Cunqueiro (Vigo)) ;
Serra Peñaranda, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Valdes Chavarri, Mariano (Centro de Investigación en Red de Enfermedades Cardiovasculares) ;
Cequier, Ángel (Hospital Universitari de Bellvitge) ;
Calvo Iglesias, Francisco (Hospital Álvaro Cunqueiro (Vigo)) ;
Iñiguez Romo, Andrés (Centro de Investigación en Red de Enfermedades Cardiovasculares) ;
Universitat Autònoma de Barcelona
The REAC-TAVI (Assessment of platelet REACtivity after Transcatheter Aortic Valve Implantation) trial enrolled patients with aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) pre-treated with aspirin + clopidogrel, aimed to compare the efficacy of clopidogrel and ticagrelor in suppressing high platelet reactivity (HPR) after TAVI. [...]
2019 - 10.1016/j.jcin.2018.10.005
JACC: Cardiovascular Interventions, Vol. 12 Núm. 1 (14 2019) , p. 22-32
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7 p, 610.3 KB |
Impact of selected comorbidities on the presentation and management of aortic stenosis
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Rudolph, Tanka K. (Ruhr-University of Bochum) ;
Messika-Zeitoun, David (University of Ottawa Heart Institute) ;
Frey, Norbert (University of Kiel) ;
Thambyrajah, Jeetendra (James Cook University Hospital) ;
Serra, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Schulz, Eberhard (AKH Celle) ;
Maly, Jiri (Charles University) ;
Aiello, Marco (Foundation IRCCS Policlinico S.Matteo) ;
Lloyd, Guy (St Bartholomew's Hospital) ;
Bortone, Alessandro Santo (University of Bari) ;
Clerici, Alberto (University of Turin) ;
Delle-Karth, Georg (Hietzing Hospital) ;
Rieber, Johannes (University of Munich) ;
Indolfi, Ciro (Magna Graecia University) ;
Mancone, Massimo (Sapienza University of Rome) ;
Belle, Loic (Centre Hospital d'Annecy) ;
Lauten, Alexander (University Heart Center and Charité) ;
Arnold, Martin (University of Erlangen) ;
Bouma, Berto J. (University of Amsterdam) ;
Lutz, Matthias (University of Kiel) ;
Deutsch, Cornelia (Institute for Pharmacology and Preventive Medicine) ;
Kurucova, Jana (Edwards Lifesciences) ;
Thoenes, Martin (Edwards Lifesciences) ;
Bramlage, Peter (Institute for Pharmacology and Preventive Medicine) ;
Steeds, Richard (University of Birmingham) ;
Universitat Autònoma de Barcelona
Contemporary data regarding the impact of comorbidities on the clinical presentation and management of patients with severe aortic stenosis (AS) are scarce. Prospective registry of severe patients with AS across 23 centres in nine European countries. [...]
2020 - 10.1136/openhrt-2020-001271
Open Heart, Vol. 7 Núm. 2 (23 2020) , p. e001271
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8 p, 2.2 MB |
Primary Angioplasty in a Catastrophic Presentation : Acute Left Main Coronary Total Occlusion - The ATOLMA Registry
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Gutierrez-Barrios, A. (Instituto de Investigacion e Innovacion en Ciencias Biomedicas de Cadiz) ;
Gheorghe, L. (Instituto de Investigacion e Innovacion en Ciencias Biomedicas de Cadiz) ;
Camacho-Freire, S. (Hospital Juan Ramon Jimenez) ;
Valencia-Serrano, F. (Hospital Torrecárdenas) ;
Canadas-Pruano, D. (Hospital de Jerez) ;
Calle Pérez, Germán (Instituto de Investigacion e Innovacion en Ciencias Biomedicas de Cadiz) ;
Alarcon De La Lastra, I. (Hospital Universitario Puerta del Mar (Cadis, Andalusia)) ;
Silva, E. (Instituto de Investigacion e Innovacion en Ciencias Biomedicas de Cadiz) ;
Garcia-Molinero, D. (Hospital Universitario Puerta del Mar (Cadis, Andalusia)) ;
Agarrado-Luna, A. (Hospital de Jerez) ;
Zayas-Ruedas, R. (Instituto de Investigacion e Innovacion en Ciencias Biomedicas de Cadiz) ;
Vazquez-Garcia, R. (Instituto de Investigacion e Innovacion en Ciencias Biomedicas de Cadiz) ;
Serra, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
To determine the outcome predictors of in-hospital mortality in acute total occlusion of the left main coronary artery (ATOLMA) patients referred to emergent angioplasty and to describe the clinical presentation and the long-term outcome of these patients. [...]
2020 - 10.1155/2020/5246504
Journal of Interventional Cardiology, Vol. 2020 (2020) , p. 5246504
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5 p, 1.0 MB |
Aortic Sinus Contrast Retention During TAVR : A Warning Sign Preceding a Potential Thrombotic Complication
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Asmarats, Lluís (Institut d'Investigació Biomèdica Sant Pau) ;
Li, Chi Hion (Institut d'Investigació Biomèdica Sant Pau) ;
Millán, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
Menduiña, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
Fernández-Peregrina, Esefanía (Institut d'Investigació Biomèdica Sant Pau) ;
Gutiérrez-Alonso, Lola (Institut d'Investigació Biomèdica Sant Pau) ;
Torres, Mario (Institut d'Investigació Biomèdica Sant Pau) ;
Serra, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Arzamendi, Dabit (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Sinus contrast material retention after transcatheter aortic valve replacement (TAVR) is a rare phenomenon that may reflect an increased risk for thrombotic complications. We present 3 cases of persistent contrast agent retention in the sinus of Valsalva during the TAVR procedure that portend the occurrence of embolic stroke or bioprosthetic valve thrombosis. [...]
2022 - 10.1016/j.jaccas.2022.03.031
JACC Case Reports, Vol. 4 Núm. 11 (january 2022) , p. 666-670
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9 p, 874.8 KB |
IMPULSE : The impact of gender on the presentation and management of aortic stenosis across Europe
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Steeds, Richard (Queen Elizabeth Hospital and Institute of Cardiovascular Sciences. University of Birmingham) ;
Messika-Zeitoun, David (University of Ottawa Heart Institute) ;
Thambyrajah, Jeetendra (James Cook University Hospital) ;
Serra, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Schulz, Eberhard (Cardiology Department. AKH Celle) ;
Maly, Jiri (Department of Cardiovascular Surgery. Second Faculty of Medicine. Charles University) ;
Aiello, Marco (Department of Cardiothoracic Surgery. Foundation IRCCS Policlinico S.Matteo) ;
Rudolph, Tanja K. (Department of Cardiology. Heart and Diabetes Center Bad Oeynhausen. Ruhr-University of Bochum) ;
Lloyd, Guy (St Bartholomew's Hospital) ;
Bortone, Alessandro Santo (University of Bari) ;
Clerici, Alberto (University of Turin) ;
Delle-Karth, Georg (4th Medical Department. Hietzing Hospital) ;
Rieber, Johannes (Herzkatheterlabor Nymphenburg and Department of Cardiology. University of Munich) ;
Indolfi, Ciro (Division of Cardiology and URT CNR of IFC. University Magna Graecia) ;
Mancone, Massimo (Sapienza University of Rome) ;
Belle, Loic (Centre Hospital d'Annecy) ;
Lauten, Alexander (Department for Cardiology. Helios Erfurt Clinic) ;
Arnold, Martin (Department of Cardiology. University of Erlangen) ;
Bouma, Berto J. (University of Amsterdam) ;
Lutz, Matthias (University of Kiel. Department of Cardiology and Angiology) ;
Deutsch, Cornelia (Institute for Pharmacology and Preventive Medicine) ;
Kurucova, Jana (Edwards Lifesciences) ;
Thoenes, Martin (Edwards Lifesciences) ;
Bramlage, Peter (Institute for Pharmacology and Preventive Medicine) ;
Frey, Norbert (Department of Cardiology and Angiology. University of Kiel)
Aims There is an increasing awareness of gender-related differences in patients with severe aortic stenosis and their outcomes after surgical aortic valve replacement (SAVR) and transcatheter aortic valve implantation (TAVI). [...]
2021 - 10.1136/openhrt-2020-001443
Open Heart, Vol. 8 Núm. 1 (august 2021) , p. e001443
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11 p, 1.9 MB |
Management of patients with severe aortic stenosis in the TAVI-era : How recent recommendations are translated into clinical practice
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Lauten, Alexander (Department for Cardiology. Helios Clinic) ;
Rudolph, Tanja K. (Department of Cardiology. Hear and Diabetes Center Bad Oeynhausen. Ruhr-University of Bochum) ;
Messika-Zeitoun, David (University of Ottawa Heart Institute) ;
Thambyrajah, Jeetendra (James Cook University Hospital) ;
Serra, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Schulz, Eberhard (Cardiology Department. Akh Celle) ;
Frey, Norbert (Department of Cardiology and Angiology. University of Kiel) ;
Maly, Jiri (Department of Cardiovascular Surgery. Second Faculty of Medicine. Charles University) ;
Aiello, Marco (Department of Cardiothoracic Surgery. Foundation Irccs Policlinico S.Matteo) ;
Lloyd, Guy (St Bartholomew's Hospital) ;
Bortone, Alessandro Santo (University of Bari) ;
Clerici, Alberto (University of Turin) ;
Delle-Karth, Georg (4th Medical Department. Hietzing Hospital) ;
Rieber, Johannes (Herzkatheterlabor Nymphenburg. Department of Cardiology. University of Munich) ;
Indolfi, Ciro (Division of Cardiology and Urt Cnr of Ifc. University Magna Graecia) ;
Mancone, Massimo (Sapienza University of Rome) ;
Belle, Loic (Centre Hospital d'Annecy) ;
Arnold, Martin (Department of Cardiology. University Hospital Erlangen) ;
Bouma, Berto J (University of Amsterdam) ;
Lutz, Matthias (University of Kiel. Department of Cardiology and Angiology) ;
Deutsch, Cornelia (Institut für Pharmakologie und Präventive Medizin GmbH) ;
Kurucova, Jana (Edwards Lifesciences) ;
Thoenes, Martin (Edwards Lifesciences) ;
Bramlage, Peter (Institut für Pharmakologie und Präventive Medizin GmbH) ;
Steeds, Richard (Queen Elizabeth Hospital. Institute of Cardiovascular Sciences. University of Birmingham)
Objective Approximately 3. 4% of adults aged >75 years suffer from aortic stenosis (AS). Guideline indications for aortic valve replacement (AVR) distinguish between patients with symptomatic and asymptomatic severe AS. [...]
2021 - 10.1136/openhrt-2020-001485
Open Heart, Vol. 8 Núm. 1 (november 2021) , p. e001485
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16 p, 1.6 MB |
Phase 2 Trial (POLA Study) of Lurbinectedin plus Olaparib in Patients with Advanced Solid Tumors : Results of Efficacy, Tolerability, and the Translational Study
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Poveda, Andres (Hospital Quironsalud (Valencia). Oncogynecologic Department) ;
Lopez-Reig, Raquel (Fundació Institut Valencià d'Oncologia) ;
Oaknin, Ana (Vall d'Hebron Institut d'Oncologia) ;
Redondo, Andres (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Rubio, Maria Jesus (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Guerra, Eva (Hospital Universitario Ramón y Cajal (Madrid)) ;
Fariñas-Madrid, Lorena (Vall d'Hebron Institut d'Oncologia) ;
Gallego, Alejandro (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Rodriguez-Freixinos, Victor (Vall d'Hebron Institut d'Oncologia) ;
Fernandez-Serra, Antonio (Fundació Institut Valencià d'Oncologia) ;
Juan, Óscar (Pivotal SLU (Madrid)) ;
Romero, Ignacio (Fundació Institut Valencià d'Oncologia) ;
López-Guerrero, J.A (Fundació Institut Valencià d'Oncologia)
Genomic instability (GI) is a transversal phenomenon in oncology, constituting a hallmark of cancer. In gynecological malignancies, the predictive value of GI has been described and is mainly caused by alterations in the homologous recombination repair (HRR) genes, such as BRCA1/2. [...]
2022 - 10.3390/cancers14040915
Cancers, Vol. 14 Núm. 4 (february 2022)
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