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12 p, 1.9 MB Modelling acrylamide acute neurotoxicity in zebrafish larvae / Prats, Eva (CID-CSIC) ; Gómez-Canela, Cristian (IDAEA-CSIC) ; Ben-Lulu, Shani (Technion - Israel Institute of Technology) ; Ziv, Tamar (Technion - Israel Institute of Technology) ; Padrós, Francesc 1965- (Universitat Autònoma de Barcelona. Servei de Diagnòstic Patològic en Peixos) ; Tornero, Daniel (IDAEA-CSIC) ; Garcia-Reyero, Natàlia (Environmental Laboratory-US Army Engineer Research and Development Center) ; Tauler, Romà (IDAEA-CSIC) ; Admon, Arie (Technion - Israel Institute of Technology) ; Raldúa, Demetrio (IDAEA-CSIC)
Acrylamide (ACR), a type-2 alkene, may lead to a synaptopathy characterized by ataxia, skeletal muscles weakness and numbness of the extremities in exposed human and laboratory animals. Currently, only the mildly affected patients undergo complete recovery, and identification of new molecules with therapeutic bioactivity against ACR acute neurotoxicity is urgently needed. [...]
2017 - 10.1038/s41598-017-14460-3
Scientific reports, Vol. 7 (october 2017)  

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