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22 p, 8.7 MB Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer / Waryah, Charlene (University of Western Australia) ; Cursons, Joseph (Monash University, Australia) ; Foroutan, Momeneh (Department of Biochemistry and Molecular Biology. Monash University, Australia) ; Pflueger, Christian (University of Western Australia) ; Wang, Edina (University of Western Australia) ; Molania, Ramyar (University of Melbourne, Australia) ; Woodward, Eleanor (Harry Perkins Institute of Medical Research, Australia) ; Sorolla, Anabel (University of Western Australia) ; Wallis, Christopher (University of Western Australia) ; Moses, Colette (University of Amsterdam, The Netherlands) ; Glas, Irina (Harry Perkins Institute of Medical Research, Australia) ; Magalhães, Leandro (University of Pará, Brazil) ; Thompson, Erik W. (Queensland University of Technology, Brisbane, Australia) ; Fearnley, Liam G. (University of Melbourne, Australia) ; Chaffer, Christine L. (St Vincent's Clinical School. UNSW Medicine, Australia) ; Davis, Melissa (University of Melbourne, Australia) ; Papenfuss, Anthony T. (University of Melbourne, Australia) ; Redfern, Andrew (University of Western Australia) ; Lister, Ryan (The University of Western Australia) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Blancafort, Pilar (University of Western Australia)
Epithelial-mesenchymal transition (EMT) is a reversible transcriptional program invoked by cancer cells to drive cancer progression. Transcription factor ZEB1 is a master regulator of EMT, driving disease recurrence in poor-outcome triple negative breast cancers (TNBCs). [...]
2023 - 10.1002/advs.202301802
Advanced science, Vol. 10 Núm. 22 (august 2023)  
Registre complet - Creative Commons

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